4zjc: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4zjc ~~is ON HOLD until Paper Publication~~

==Structures of the human OX1 orexin receptor bound to selective and dual antagonists==

~~Authors~~: ~~Yin, J~~.~~, Brautigam, C~~.A.~~, Shao, Z~~.~~, Clark, L~~.~~, Harrell, C~~.M.~~, Gotter, A~~.L., ~~Coleman~~, ~~P.J.~~, ~~Renger~~, ~~J.J., Rosenbaum, D.M.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4zjc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJC OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZJC FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=4OT:[5-(2-FLUOROPHENYL)-2-METHYL-1,3-THIAZOL-4-YL]{(2S)-2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)METHYL]PYRROLIDIN-1-YL}METHANONE'>4OT</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4zj8|4zj8]]</td></tr>

[[~~Category~~: ~~Coleman~~, P.J]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjc OCA], [http://pdbe.org/4zjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zjc RCSB], [http://www.ebi.ac.uk/pdbsum/4zjc PDBsum]</td></tr>

[[~~Category~~: ~~Harrell, C~~.M]]

</table>

[[~~Category~~: ~~Renger, J~~.J]]

== Function ==

[[Category: ~~Gotter~~, A.L]]

[[http://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN]] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).

__TOC__

</StructureSection>

[[Category: Brautigam, C A]]

[[Category: Clark, L]]

[[Category: Coleman, P J]]

[[Category: Gotter, A L]]

[[Category: Harrell, C M]]

[[Category: Renger, J J]]

[[Category: Rosenbaum, D M]]

[[Category: Shao, Z]]

~~[[Category: Rosenbaum, D.M]]~~

~~[[Category: Brautigam, C.A]]~~

[[Category: Yin, J]]

[[Category: Membrane protein-transferase complex]]

[[Category: Orexin]]

[[Category: Sb-674042]]

[[Category: Signaling protein]]

[[Category: Suvorexant]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4zjc is ON HOLD  until Paper Publication
+==Structures of the human OX1 orexin receptor bound to selective and dual antagonists==
+<StructureSection load='4zjc' size='340' side='right' caption='[[4zjc]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
-Authors: Yin, J., Brautigam, C.A., Shao, Z., Clark, L., Harrell, C.M., Gotter, A.L., Coleman, P.J., Renger, J.J., Rosenbaum, D.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4zjc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZJC FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4OT:[5-(2-FLUOROPHENYL)-2-METHYL-1,3-THIAZOL-4-YL]{(2S)-2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)METHYL]PYRROLIDIN-1-YL}METHANONE'>4OT</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zj8|4zj8]]</td></tr>
-[[Category: Coleman, P.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjc OCA], [http://pdbe.org/4zjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zjc RCSB], [http://www.ebi.ac.uk/pdbsum/4zjc PDBsum]</span></td></tr>
-[[Category: Harrell, C.M]]
+</table>
-[[Category: Renger, J.J]]
+== Function ==
-[[Category: Gotter, A.L]]
+[[http://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN]] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Brautigam, C A]]
 [[Category: Clark, L]]
+[[Category: Coleman, P J]]
+[[Category: Gotter, A L]]
+[[Category: Harrell, C M]]
+[[Category: Renger, J J]]
+[[Category: Rosenbaum, D M]]
 [[Category: Shao, Z]]
-[[Category: Rosenbaum, D.M]]
-[[Category: Brautigam, C.A]]
 [[Category: Yin, J]]
+[[Category: Membrane protein-transferase complex]]
+[[Category: Orexin]]
+[[Category: Sb-674042]]
+[[Category: Signaling protein]]
+[[Category: Suvorexant]]