4zv8: Difference between revisions
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==Structure of CYP2B6 (Y226H/K262R) with additional mutation Y244W in complex with alpha-Pinene== | |||
<StructureSection load='4zv8' size='340' side='right' caption='[[4zv8]], [[Resolution|resolution]] 2.24Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4zv8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZV8 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TMH:(+)-ALPHA-PINENE'>TMH</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i91|4i91]], [[4rrt|4rrt]], [[4rql|4rql]], [[3ibd|3ibd]], [[3qoa|3qoa]], [[3qu8|3qu8]], [[3ua5|3ua5]]</td></tr> | ||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv8 OCA], [http://pdbe.org/4zv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4zv8 PDBsum]</span></td></tr> | ||
[[ | </table> | ||
[[Category: Halpert, J | == Function == | ||
[[http://www.uniprot.org/uniprot/CP2B6_HUMAN CP2B6_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.<ref>PMID:11695850</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Halpert, J R]] | |||
[[Category: Liu, J]] | [[Category: Liu, J]] | ||
[[Category: Shah, M B]] | |||
[[Category: Stout, C D]] | |||
[[Category: Cytochrome p450 2b6]] | |||
[[Category: Monoxygenase]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 20:27, 11 May 2016
Structure of CYP2B6 (Y226H/K262R) with additional mutation Y244W in complex with alpha-Pinene
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