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==THE CRYSTAL STRUCTURE OF I-SCEI IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF MN== | |||
<StructureSection load='5a0m' size='340' side='right' caption='[[5a0m]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5a0m]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A0M FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0m OCA], [http://pdbe.org/5a0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a0m RCSB], [http://www.ebi.ac.uk/pdbsum/5a0m PDBsum]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SCE1_YEAST SCE1_YEAST]] Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the 21S rRNA gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Specifically recognizes and cleaves the sequence 5'-TAGGGATAACAGGGTAAT-3'. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Blanco, F J]] | |||
[[Category: Merino, N]] | |||
[[Category: Molina, R]] | |||
[[Category: Prieto, J]] | [[Category: Prieto, J]] | ||
[[Category: | [[Category: Redondo, P]] | ||
[[Category: Villate, M]] | [[Category: Villate, M]] | ||
[[Category: | [[Category: Gene targeting]] | ||
[[Category: Genetic]] | |||
[[Category: Homing endonuclease]] | |||
[[Category: Hydrolase-dna complex]] | |||
[[Category: Protein-dna interaction]] | |||
Revision as of 19:34, 13 May 2016
THE CRYSTAL STRUCTURE OF I-SCEI IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF MN
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