5a4n: Difference between revisions
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==Crystal structure of BPSL1147, a PC4 homolog from Burkholderia pseudomallei K96243 (tetragonal crystal form)== | |||
<StructureSection load='5a4n' size='340' side='right' caption='[[5a4n]], [[Resolution|resolution]] 1.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5a4n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A4N FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a4o|5a4o]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a4n OCA], [http://pdbe.org/5a4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a4n RCSB], [http://www.ebi.ac.uk/pdbsum/5a4n PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Homologs of the eukaryotic transcription coactivator PC4, which also functions in DNA repair and oxidative stress, were recently identified in prokaryotes. Crystallographic analysis of BPSL1147, a putative homolog from the pathogen Burkholderia pseudomallei K96243, reveals a highly conserved core structure and suggests a nucleic acid binding mode similar to that of PC4. Knock-out and complementation experiments do not reveal distinguishing phenotypes under normal growth conditions or in the presence of H2O2, arguing against a critical role in repair or the oxidative stress response of Burkholderia. These results may reflect redundancy or point at a bacteriophage origin of Burkholderia PC4 homologs. | |||
Structural analysis and knock-out of a Burkholderia pseudomallei homolog of the eukaryotic transcription coactivator PC4.,Werten S, Kohler C, Bayer NJ, Steinmetz I, Hinrichs W Gene. 2016 Feb 15;577(2):140-7. doi: 10.1016/j.gene.2015.11.037. Epub 2015 Nov, 25. PMID:26625975<ref>PMID:26625975</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5a4n" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bayer, N]] | |||
[[Category: Hinrichs, W]] | [[Category: Hinrichs, W]] | ||
[[Category: Werten, S]] | [[Category: Werten, S]] | ||
[[Category: | [[Category: Dna replication]] | ||
[[Category: Dna-binding protein]] | |||
[[Category: Recombination and repair]] | |||
[[Category: Transcription]] | |||
Revision as of 04:04, 12 May 2016
Crystal structure of BPSL1147, a PC4 homolog from Burkholderia pseudomallei K96243 (tetragonal crystal form)
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