5e8j: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5e8j is ~~ON HOLD until Paper Publication~~

==Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with RAM==

~~Authors~~: ~~Petit~~, P., ~~Cowling~~, V.

== Structural highlights ==

<table><tr><td colspan='2'>[[5e8j]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8J OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E8J FirstGlance].

~~Description~~: ~~Crystal~~ structure of mRNA cap ~~guanine~~-~~N7 methyltransferase in complex with RAM~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[3bgv|3bgv]], [[3epp|3epp]]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/mRNA_(guanine-N(7)-)-methyltransferase mRNA (guanine-N(7)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.56 2.1.1.56] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8j OCA], [http://pdbe.org/5e8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e8j RCSB], [http://www.ebi.ac.uk/pdbsum/5e8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e8j ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/MCES_HUMAN MCES_HUMAN]] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:9790902</ref> <ref>PMID:9705270</ref> <ref>PMID:10347220</ref> <ref>PMID:22099306</ref> [[http://www.uniprot.org/uniprot/RAM_HUMAN RAM_HUMAN]] Required for efficient mRNA cap methylation. Regulates RNMT expression by a post-transcriptional stabilizing mechanism.<ref>PMID:22099306</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Cowling, V]]

[[Category: Petit, P]]

[[Category: ~~Cowling, V~~]]

[[Category: Mrna capping]]

[[Category: Mrna processing]]

[[Category: Translation]]

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-'''Unreleased structure'''
-The entry 5e8j is ON HOLD  until Paper Publication
+==Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with RAM==
+<StructureSection load='5e8j' size='340' side='right' caption='[[5e8j]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-Authors: Petit, P., Cowling, V.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5e8j]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E8J FirstGlance]. <br>
-Description: Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with RAM
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bgv|3bgv]], [[3epp|3epp]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_(guanine-N(7)-)-methyltransferase mRNA (guanine-N(7)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.56 2.1.1.56] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8j OCA], [http://pdbe.org/5e8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e8j RCSB], [http://www.ebi.ac.uk/pdbsum/5e8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e8j ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MCES_HUMAN MCES_HUMAN]] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:9790902</ref> <ref>PMID:9705270</ref> <ref>PMID:10347220</ref> <ref>PMID:22099306</ref>  [[http://www.uniprot.org/uniprot/RAM_HUMAN RAM_HUMAN]] Required for efficient mRNA cap methylation. Regulates RNMT expression by a post-transcriptional stabilizing mechanism.<ref>PMID:22099306</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Cowling, V]]
 [[Category: Petit, P]]
-[[Category: Cowling, V]]
+[[Category: Mrna capping]]
+[[Category: Mrna processing]]
+[[Category: Translation]]