5ec1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ec1 ~~is ON HOLD until Paper Publication~~

==KcsA with V76ester mutation==

~~Authors~~: ~~Matulef, K~~.~~, Valiyaveetil, F~~.I.

== Structural highlights ==

<table><tr><td colspan='2'>[[5ec1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EC1 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EC1 FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=LHV:(2S)-2-HYDROXY-3-METHYLBUTANOIC+ACID'>LHV</scene></td></tr>

[[~~Category~~: ~~Valiyaveetil~~, F.I]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ec1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ec1 OCA], [http://pdbe.org/5ec1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ec1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ec1 PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Matulef, K]]

[[Category: Valiyaveetil, F I]]

[[Category: Alpha helical]]

[[Category: Channel]]

[[Category: Fab]]

[[Category: Membrane protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ec1 is ON HOLD  until Paper Publication
+==KcsA with V76ester mutation==
+<StructureSection load='5ec1' size='340' side='right' caption='[[5ec1]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
-Authors: Matulef, K., Valiyaveetil, F.I.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ec1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EC1 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LHV:(2S)-2-HYDROXY-3-METHYLBUTANOIC+ACID'>LHV</scene></td></tr>
-[[Category: Valiyaveetil, F.I]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ebl|5ebl]], [[5ebm|5ebm]], [[5ebw|5ebw]], [[5ec2|5ec2]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ec1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ec1 OCA], [http://pdbe.org/5ec1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ec1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ec1 PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Matulef, K]]
+[[Category: Valiyaveetil, F I]]
+[[Category: Alpha helical]]
+[[Category: Channel]]
+[[Category: Fab]]
+[[Category: Membrane protein]]