5efq: Difference between revisions

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'''~~Unreleased structure~~'''

==Crystal structure of human Cdk13/Cyclin K in complex with ADP-aluminum fluoride==

~~The entry~~ 5efq is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5efq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EFQ OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EFQ FirstGlance].

~~Authors~~: ~~Hoenig~~, D., ~~Greifenberg~~, A.K., ~~Anand~~, K., ~~Geyer~~, M.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>

~~Description~~:

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5efq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5efq OCA], [http://pdbe.org/5efq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5efq RCSB], [http://www.ebi.ac.uk/pdbsum/5efq PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CDK13_HUMAN CDK13_HUMAN]] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.<ref>PMID:16721827</ref> <ref>PMID:1731328</ref> <ref>PMID:18480452</ref> <ref>PMID:20952539</ref> [[http://www.uniprot.org/uniprot/CCNK_HUMAN CCNK_HUMAN]] May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).<ref>PMID:10574912</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Anand, K]]

~~[[Category: Greifenberg, A.K]]~~

[[Category: Geyer, M]]

[[Category: Greifenberg, A K]]

[[Category: Hoenig, D]]

[[Category: Adp]]

[[Category: Cyclin]]

[[Category: Kinase]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of human Cdk13/Cyclin K in complex with ADP-aluminum fluoride==
+<StructureSection load='5efq' size='340' side='right' caption='[[5efq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-The entry 5efq is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5efq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EFQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EFQ FirstGlance]. <br>
-Authors: Hoenig, D., Greifenberg, A.K., Anand, K., Geyer, M.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-Description:
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5efq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5efq OCA], [http://pdbe.org/5efq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5efq RCSB], [http://www.ebi.ac.uk/pdbsum/5efq PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CDK13_HUMAN CDK13_HUMAN]] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.<ref>PMID:16721827</ref> <ref>PMID:1731328</ref> <ref>PMID:18480452</ref> <ref>PMID:20952539</ref>  [[http://www.uniprot.org/uniprot/CCNK_HUMAN CCNK_HUMAN]] May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).<ref>PMID:10574912</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Anand, K]]
-[[Category: Greifenberg, A.K]]
 [[Category: Geyer, M]]
+[[Category: Greifenberg, A K]]
 [[Category: Hoenig, D]]
+[[Category: Adp]]
+[[Category: Cyclin]]
+[[Category: Kinase]]
+[[Category: Transferase]]