5emo: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structure of the star domain of T-STAR in complex with AUUAAA RNA==

~~The entry~~ 5emo is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5emo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EMO FirstGlance]. <br>

~~Authors~~: ~~Dominguez~~, C., ~~Feracci~~, M.

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emo OCA], [http://pdbe.org/5emo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5emo RCSB], [http://www.ebi.ac.uk/pdbsum/5emo PDBsum]</span></td></tr>

</table>

~~Description~~: ~~Structure~~ of ~~the star domain~~ of T-~~STAR~~ in ~~complex with AUUAAA~~ RNA

== Function ==

[~~[Category~~: ~~Unreleased Structures]]~~

[[http://www.uniprot.org/uniprot/KHDR3_HUMAN KHDR3_HUMAN]] RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro.<ref>PMID:10564820</ref> <ref>PMID:11741900</ref> <ref>PMID:15901763</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Dominguez, C]]

[[Category: Feracci, M]]

[[Category: Protein - rna complexes star protein alternative splicing kh domain]]

[[Category: Rna binding protein]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structure of the star domain of T-STAR in complex with AUUAAA RNA==
+<StructureSection load='5emo' size='340' side='right' caption='[[5emo]], [[Resolution|resolution]] 3.03&Aring;' scene=''>
-The entry 5emo is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5emo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EMO FirstGlance]. <br>
-Authors: Dominguez, C., Feracci, M.
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emo OCA], [http://pdbe.org/5emo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5emo RCSB], [http://www.ebi.ac.uk/pdbsum/5emo PDBsum]</span></td></tr>
+</table>
-Description: Structure of the star domain of T-STAR in complex with AUUAAA RNA
+== Function ==
-[[Category: Unreleased Structures]]
+[[http://www.uniprot.org/uniprot/KHDR3_HUMAN KHDR3_HUMAN]] RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro.<ref>PMID:10564820</ref> <ref>PMID:11741900</ref> <ref>PMID:15901763</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Dominguez, C]]
 [[Category: Feracci, M]]
+[[Category: Protein - rna complexes star protein alternative splicing kh domain]]
+[[Category: Rna binding protein]]