5enb: Difference between revisions
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==Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with o-Tolylthiourea (SGC - Diamond I04-1 fragment screening)== | |||
<StructureSection load='5enb' size='340' side='right' caption='[[5enb]], [[Resolution|resolution]] 1.73Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5enb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ENB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ENB FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5Q5:1-(2-METHYLPHENYL)THIOUREA'>5Q5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5enb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5enb OCA], [http://pdbe.org/5enb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5enb RCSB], [http://www.ebi.ac.uk/pdbsum/5enb PDBsum]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN]] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Bradley, A]] | |||
[[Category: Brennan, P]] | |||
[[Category: Burgess-Brown, N]] | [[Category: Burgess-Brown, N]] | ||
[[Category: Collins, P]] | [[Category: Collins, P]] | ||
[[Category: Cox, O]] | [[Category: Cox, O]] | ||
[[Category: | [[Category: Delft, F von]] | ||
[[Category: Edwards, A]] | |||
[[Category: Krojer, T]] | |||
[[Category: Structural genomic]] | |||
[[Category: Szykowska, A]] | [[Category: Szykowska, A]] | ||
[[Category: Talon, R]] | [[Category: Talon, R]] | ||
[[Category: | [[Category: Bromodomain]] | ||
[[Category: | [[Category: Crystallographic fragment screen]] | ||
[[Category: | [[Category: Phip]] | ||
[[Category: | [[Category: Sgc]] | ||
[[Category: Signaling protein]] | |||
[[Category: Transcription]] | |||
Revision as of 12:02, 13 May 2016
Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with o-Tolylthiourea (SGC - Diamond I04-1 fragment screening)
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