5epk: Difference between revisions

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'''Unreleased structure'''
==Crystal Structure of chromodomain of CBX2 in complex with inhibitor UNC3866==
 
<StructureSection load='5epk' size='340' side='right' caption='[[5epk]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
The entry 5epk is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5epk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EPK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EPK FirstGlance]. <br>
Authors: Liu, Y., Tempel, W., Walker, J.R., Dickson, B.M., James, L.I., Frye, S.V., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
 
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5R0:4-~{TERT}-BUTYLBENZOIC+ACID'>5R0</scene>, <scene name='pdbligand=5R5:METHYL+(2~{S})-2-AZANYL-3-OXIDANYL-PROPANOATE'>5R5</scene>, <scene name='pdbligand=ELY:N~6~,N~6~-DIETHYL-L-LYSINE'>ELY</scene></td></tr>
Description: Crystal Structure of chromodomain of CBX2 in complex with inhibitor UNC3866
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5epl|5epl]], [[5epj|5epj]]</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5epk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5epk OCA], [http://pdbe.org/5epk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5epk RCSB], [http://www.ebi.ac.uk/pdbsum/5epk PDBsum]</span></td></tr>
[[Category: James, L.I]]
</table>
[[Category: Frye, S.V]]
== Disease ==
[[Category: Dickson, B.M]]
[[http://www.uniprot.org/uniprot/CBX2_HUMAN CBX2_HUMAN]] Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5) [MIM:[http://omim.org/entry/613080 613080]]. It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.<ref>PMID:19361780</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/CBX2_HUMAN CBX2_HUMAN]] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.<ref>PMID:19361780</ref> <ref>PMID:21282530</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Dickson, B M]]
[[Category: Edwards, A M]]
[[Category: Frye, S V]]
[[Category: James, L I]]
[[Category: Liu, Y]]
[[Category: Min, J]]
[[Category: Min, J]]
[[Category: Walker, J.R]]
[[Category: Structural genomic]]
[[Category: Liu, Y]]
[[Category: Bountra, C]]
[[Category: Tempel, W]]
[[Category: Tempel, W]]
[[Category: Arrowsmith, C.H]]
[[Category: Walker, J R]]
[[Category: Edwards, A.M]]
[[Category: Sgc]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Transcription-transcription inhibitor complex]]
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