5eql: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5eql ~~is ON HOLD until Paper Publication~~

==Isoform-specific inhibition of SUMO-dependent protein-protein interactions==

~~Authors~~: ~~Hughes, D~~.J.~~, Tiede, C~~.~~, Hall, N~~.~~, Tang, A~~.A.S.~~, Trinh, C~~.H.~~, Zajac, K~~.~~, Mandal, U~~., ~~Howell, G~~.~~, Edwards, T~~.A., ~~McPherson~~, M.J., ~~Tomlinson, D~~.C., ~~Whitehouse, A~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5eql]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EQL FirstGlance]. <br>

~~Description: Isoform-specific inhibition of SUMO-dependent protein-protein interactions~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eql OCA], [http://pdbe.org/5eql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eql RCSB], [http://www.ebi.ac.uk/pdbsum/5eql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eql ProSAT]</span></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

[[Category: ~~Whitehouse~~, A]]

== Function ==

[[http://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Edwards, T A]]

[[Category: Hall, N]]

[[Category: ~~Trinh~~, ~~C.H~~]]

[[Category: Howell, G]]

[[Category: ~~Tomlinson~~, D.C]]

[[Category: Hughes, D J]]

[[Category: ~~Tang~~, ~~A.A.S~~]]

[[Category: Mandal, U]]

[[Category: ~~Edwards~~, ~~T.A~~]]

[[Category: McPherson, M J]]

[[Category: ~~Mcpherson~~, M.J]]

[[Category: Tang, A A.S]]

[[Category: Tiede, C]]

[[Category: ~~Howell~~, G]]

[[Category: Tomlinson, D C]]

[[Category: Trinh, C H]]

[[Category: Whitehouse, A]]

[[Category: Zajac, K]]

[[Category: ~~Hughes, D.J~~]]

[[Category: Protein binding]]

[[Category: ~~Mandal, U~~]]

[[Category: Sumoylation]]

[[Category: Ubiquitin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5eql is ON HOLD  until Paper Publication
+==Isoform-specific inhibition of SUMO-dependent protein-protein interactions==
+<StructureSection load='5eql' size='340' side='right' caption='[[5eql]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
-Authors: Hughes, D.J., Tiede, C., Hall, N., Tang, A.A.S., Trinh, C.H., Zajac, K., Mandal, U., Howell, G., Edwards, T.A., McPherson, M.J., Tomlinson, D.C., Whitehouse, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5eql]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EQL FirstGlance]. <br>
-Description: Isoform-specific inhibition of SUMO-dependent protein-protein interactions
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eql OCA], [http://pdbe.org/5eql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eql RCSB], [http://www.ebi.ac.uk/pdbsum/5eql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eql ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Whitehouse, A]]
+== Function ==
+[[http://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Edwards, T A]]
 [[Category: Hall, N]]
-[[Category: Trinh, C.H]]
+[[Category: Howell, G]]
-[[Category: Tomlinson, D.C]]
+[[Category: Hughes, D J]]
-[[Category: Tang, A.A.S]]
+[[Category: Mandal, U]]
-[[Category: Edwards, T.A]]
+[[Category: McPherson, M J]]
-[[Category: Mcpherson, M.J]]
+[[Category: Tang, A A.S]]
 [[Category: Tiede, C]]
-[[Category: Howell, G]]
+[[Category: Tomlinson, D C]]
+[[Category: Trinh, C H]]
+[[Category: Whitehouse, A]]
 [[Category: Zajac, K]]
-[[Category: Hughes, D.J]]
+[[Category: Protein binding]]
-[[Category: Mandal, U]]
+[[Category: Sumoylation]]
+[[Category: Ubiquitin]]