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'''TYPE-2 CU-DEPLETED LACCASE FROM COPRINUS CINEREUS''' | '''TYPE-2 CU-DEPLETED LACCASE FROM COPRINUS CINEREUS''' | ||
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[[Category: Brzozowski, W.]] | [[Category: Brzozowski, W.]] | ||
[[Category: Ducros, V.]] | [[Category: Ducros, V.]] | ||
[[Category: | [[Category: Blue multi-copper oxidase]] | ||
[[Category: | [[Category: Glycoprotein]] | ||
[[Category: | [[Category: Laccase]] | ||
[[Category: | [[Category: Oxidoreductase]] | ||
[[Category: | [[Category: Signal]] | ||
[[Category: | [[Category: Type-2 copper depleted]] | ||
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Revision as of 06:52, 2 May 2008
TYPE-2 CU-DEPLETED LACCASE FROM COPRINUS CINEREUS
Overview
Laccase catalyses the oxidation of a variety of organic substrates coupled to the reduction of oxygen to water. It is widely believed to be the simplest representative of the ubiquitous blue multi-copper oxidase family. Laccase is implicated in a wide spectrum of biological activities and, in particular, plays a key role in morphogenesis, development and lignin metabolism in fungi and plants. The structure of laccase from the fungus Coprinus cinereus has been determined by X-ray crystallography at a resolution of 2.2 A. Laccase is a monomer composed of three cupredoxin-like beta-sandwich domains, similar to that found in ascorbate oxidase. In contrast to ascorbate oxidase, however, the mononuclear type-1 Cu site lacks the axial methionine ligand and so exhibits trigonal planar coordination, consistent with its elevated redox potential. Crucially, the structure is trapped in a Cu depleted form in which the putative type-2 Cu atom is completely absent, but in which the remaining type-1 and type-3 Cu sites display full occupancy. Type-2 Cu depletion has unexpected consequences for the coordination of the remaining type-3 Cu atoms.
About this Structure
1A65 is a Single protein structure of sequence from Coprinopsis cinerea. Full crystallographic information is available from OCA.
Reference
Crystal structure of the type-2 Cu depleted laccase from Coprinus cinereus at 2.2 A resolution., Ducros V, Brzozowski AM, Wilson KS, Brown SH, Ostergaard P, Schneider P, Yaver DS, Pedersen AH, Davies GJ, Nat Struct Biol. 1998 Apr;5(4):310-6. PMID:9546223 Page seeded by OCA on Fri May 2 09:52:11 2008
