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'''Unreleased structure'''
==Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180==
 
<StructureSection load='5fn0' size='340' side='right' caption='[[5fn0]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
The entry 5fn0 is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5fn0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FN0 FirstGlance]. <br>
Authors: Mole, D.J., Webster, S.P., Uings, I., Zheng, X., Binnie, M., Wilson, K., Hutchinson, J.P., Mirguet, O., Walker, A., Beaufils, B., Ancellin, N., Trottet, L., Beneton, V., Mowat, C.G., Wilkinson, M., Rowland, P., Haslam, C., McBride, A., Homer, N.Z.M., Baily, J.E., Sharp, M.G.F., Garden, O.J., Hughes, J., Howie, S.E.M., Holmes, D., Liddle, J., Iredale, J.P.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=JHY:3-(5,6-DICHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC+ACID'>JHY</scene></td></tr>
 
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kynurenine_3-monooxygenase Kynurenine 3-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.9 1.14.13.9] </span></td></tr>
Description: Crystal structure of Pseudomonas fluorescens kynurenine-3-monooxygenase (KMO) in complex with GSK180
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fn0 OCA], [http://pdbe.org/5fn0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fn0 RCSB], [http://www.ebi.ac.uk/pdbsum/5fn0 PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Iredale, J.P]]
== Function ==
[[http://www.uniprot.org/uniprot/KMO_PSEFL KMO_PSEFL]] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Probably required for the synthesis of quinolinic acid and the siderophore quinolobactin.
__TOC__
</StructureSection>
[[Category: Kynurenine 3-monooxygenase]]
[[Category: Ancellin, N]]
[[Category: Baily, J E]]
[[Category: Beaufils, B]]
[[Category: Beaufils, B]]
[[Category: Mole, D.J]]
[[Category: Beneton, V]]
[[Category: Garden, O.J]]
[[Category: Mowat, C.G]]
[[Category: Zheng, X]]
[[Category: Hughes, J]]
[[Category: Binnie, M]]
[[Category: Binnie, M]]
[[Category: Mcbride, A]]
[[Category: Garden, O J]]
[[Category: Ancellin, N]]
[[Category: Sharp, M.G.F]]
[[Category: Wilson, K]]
[[Category: Beneton, V]]
[[Category: Haslam, C]]
[[Category: Haslam, C]]
[[Category: Holmes, D]]
[[Category: Homer, N Z.M]]
[[Category: Howie, S E.M]]
[[Category: Hughes, J]]
[[Category: Hutchinson, J P]]
[[Category: Iredale, J P]]
[[Category: Liddle, J]]
[[Category: McBride, A]]
[[Category: Mirguet, O]]
[[Category: Mole, D J]]
[[Category: Mowat, C G]]
[[Category: Rowland, P]]
[[Category: Sharp, M G.F]]
[[Category: Trottet, L]]
[[Category: Uings, I]]
[[Category: Uings, I]]
[[Category: Walker, A]]
[[Category: Webster, S P]]
[[Category: Wilkinson, M]]
[[Category: Wilkinson, M]]
[[Category: Hutchinson, J.P]]
[[Category: Wilson, K]]
[[Category: Liddle, J]]
[[Category: Zheng, X]]
[[Category: Walker, A]]
[[Category: Kmo]]
[[Category: Webster, S.P]]
[[Category: Oxidoreductase]]
[[Category: Holmes, D]]
[[Category: Trottet, L]]
[[Category: Howie, S.E.M]]
[[Category: Baily, J.E]]
[[Category: Rowland, P]]
[[Category: Homer, N.Z.M]]
[[Category: Mirguet, O]]

Revision as of 20:37, 13 January 2016

Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180

5fn0, resolution 3.19Å

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