1ae7: Difference between revisions
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'''NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2''' | '''NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2''' | ||
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The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution., Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H, FEBS Lett. 1992 Apr 20;301(2):159-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1568473 1568473] | The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution., Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H, FEBS Lett. 1992 Apr 20;301(2):159-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1568473 1568473] | ||
[[Category: Notechis scutatus scutatus]] | [[Category: Notechis scutatus scutatus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Eaker, D.]] | [[Category: Eaker, D.]] | ||
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[[Category: Uhlin, U.]] | [[Category: Uhlin, U.]] | ||
[[Category: Westerlund, B.]] | [[Category: Westerlund, B.]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: | [[Category: Lipid degradation]] | ||
[[Category: | [[Category: Phospholipase a2]] | ||
[[Category: | [[Category: Presynaptic neurotoxin]] | ||
[[Category: | [[Category: Venom]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:09:10 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 07:09, 2 May 2008
NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2
Overview
The three-dimensional structure of notexin has been solved by molecular replacement methods. The structure has been refined at 2.0 A resolution to a crystallographic R-value of 16.5% with good stereo-chemistry. The core of the protein is very similar to other phospholipase A2s (PLA2 s) but several parts of the molecule are distinctly different. The most significant differences from PLA2 s from bovine pancreas and rattlesnake occur in the stretches 56-80 and 85-89. Residue 69, which has been shown to be important for phospholipase binding, has a different conformation and different interactions than in other known PLA2s. The C alpha positions for residues 86-88 differ by about 6 A from both the bovine and the rattlesnake enzyme. The crystals contain no Ca2+ ions. Instead, a water molecule occupies the calcium site.
About this Structure
1AE7 is a Single protein structure of sequence from Notechis scutatus scutatus. Full crystallographic information is available from OCA.
Reference
The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution., Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H, FEBS Lett. 1992 Apr 20;301(2):159-64. PMID:1568473 Page seeded by OCA on Fri May 2 10:09:10 2008
