Sandbox 77: Difference between revisions
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== 5-HT1B (and 5HT-2B) receptor agonists: Lysergic Acid Diethylamide (LSD)== | == 5-HT1B (and 5HT-2B) receptor agonists: Lysergic Acid Diethylamide (LSD)== | ||
Lysergic Acid Diethylamide, more commonly known as LSD, is a potent hallucinogen and non-selective 5-HT receptor agonist, meaning it can bind with equal affinity to two or more receptors. LSD actively binds in the orthosteric binding pocket to both the 5-HT1B and 5HT-2B receptors, suggesting a similar chemical structure and function between the two receptor families (Wang, 2013). The docking is stabilized by hydrogen bonding between the amino group of the 5-membered ring of the threonine residue of the 5-HT1B receptor, in a similar fashion that 5-HT would bind to said receptor. | Lysergic Acid Diethylamide, more commonly known as LSD, is a potent hallucinogen and non-selective 5-HT receptor agonist, meaning it can bind with equal affinity to two or more receptors. LSD actively binds in the orthosteric binding pocket to both the 5-HT1B and 5HT-2B receptors, suggesting a similar chemical structure and function between the two receptor families (Wang, 2013). The docking is stabilized by hydrogen bonding between the amino group of the 5-membered ring of LSD and the threonine residue of the 5-HT1B receptor, in a similar fashion that 5-HT would bind to said receptor. | ||
