Sandbox 77: Difference between revisions

Line 13:

== 5-HT1B (and 5HT-2B) receptor agonists: Lysergic Acid Diethylamide (LSD)==

Lysergic Acid Diethylamide, more commonly known as LSD, is a potent hallucinogen and non-selective 5-HT receptor agonist, meaning it can bind with equal affinity to two or more receptors. LSD actively binds in the orthosteric binding pocket to both the 5-HT1B and 5HT-2B receptors, suggesting a similar chemical structure and function between the two receptor families <ref name = "one" />. The docking is stabilized by hydrogen bonding between the amino group of the 5-membered ring of LSD and the threonine residue of the 5-HT1B receptor, in a similar fashion that 5-HT would bind to said receptor.

Lysergic Acid Diethylamide, more commonly known as LSD, is a potent hallucinogen and is derived from ergotamine, an ergopeptine whose structural skeleton is contained in a diverse range of alkaloids. LSD acts as a non-selective 5-HT receptor agonist, meaning it can bind with equal affinity to two or more sub-types of receptors. LSD actively binds in the orthosteric binding pocket to both the 5-HT1B and 5HT-2B receptors, suggesting a similar chemical structure and function between the two receptor families <ref name = "one" />. The docking is stabilized by hydrogen bonding between the amino group of the 5-membered ring of LSD and the threonine residue of the 5-HT1B receptor, in a similar fashion that 5-HT would bind to said receptor.

==5-HT3 receptor antagonist: 4i (N-(3-chloro-2-methylphenyl)quinoxalin-2-carboxamide)==

Sandbox 77: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 13: / Line 13: @@
 == 5-HT1B (and 5HT-2B) receptor agonists: Lysergic Acid Diethylamide (LSD)==
-Lysergic Acid Diethylamide, more commonly known as LSD, is a potent hallucinogen and non-selective 5-HT receptor agonist, meaning it can bind with equal affinity to two or more receptors. LSD actively binds in the orthosteric binding pocket to both the 5-HT1B and 5HT-2B receptors, suggesting a similar chemical structure and function between the two receptor families <ref name = "one" />. The docking is stabilized by hydrogen bonding between the amino group of the 5-membered ring of LSD and the threonine residue of the 5-HT1B receptor, in a similar fashion that 5-HT would bind to said receptor.
+Lysergic Acid Diethylamide, more commonly known as LSD, is a potent hallucinogen and is derived from ergotamine, an ergopeptine whose structural skeleton is contained in a diverse range of alkaloids. LSD acts as a non-selective 5-HT receptor agonist, meaning it can bind with equal affinity to two or more sub-types of receptors. LSD actively binds in the orthosteric binding pocket to both the 5-HT1B and 5HT-2B receptors, suggesting a similar chemical structure and function between the two receptor families <ref name = "one" />. The docking is stabilized by hydrogen bonding between the amino group of the 5-membered ring of LSD and the threonine residue of the 5-HT1B receptor, in a similar fashion that 5-HT would bind to said receptor.
 ==5-HT3 receptor antagonist: 4i (N-(3-chloro-2-methylphenyl)quinoxalin-2-carboxamide)==