1aj6: Difference between revisions

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[[Image:1aj6.gif|left|200px]]
[[Image:1aj6.gif|left|200px]]


{{Structure
<!--
|PDB= 1aj6 |SIZE=350|CAPTION= <scene name='initialview01'>1aj6</scene>, resolution 2.3&Aring;
The line below this paragraph, containing "STRUCTURE_1aj6", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
|LIGAND= <scene name='pdbligand=NOV:NOVOBIOCIN'>NOV</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span>
or leave the SCENE parameter empty for the default display.
|GENE= GYRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
-->
|DOMAIN=
{{STRUCTURE_1aj6| PDB=1aj6  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aj6 OCA], [http://www.ebi.ac.uk/pdbsum/1aj6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aj6 RCSB]</span>
}}


'''NOVOBIOCIN-RESISTANT MUTANT (R136H) OF THE N-TERMINAL 24 KDA FRAGMENT OF DNA GYRASE B COMPLEXED WITH NOVOBIOCIN AT 2.3 ANGSTROMS RESOLUTION'''
'''NOVOBIOCIN-RESISTANT MUTANT (R136H) OF THE N-TERMINAL 24 KDA FRAGMENT OF DNA GYRASE B COMPLEXED WITH NOVOBIOCIN AT 2.3 ANGSTROMS RESOLUTION'''
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==Reference==
==Reference==
The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study., Holdgate GA, Tunnicliffe A, Ward WH, Weston SA, Rosenbrock G, Barth PT, Taylor IW, Pauptit RA, Timms D, Biochemistry. 1997 Aug 12;36(32):9663-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9245398 9245398]
The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study., Holdgate GA, Tunnicliffe A, Ward WH, Weston SA, Rosenbrock G, Barth PT, Taylor IW, Pauptit RA, Timms D, Biochemistry. 1997 Aug 12;36(32):9663-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9245398 9245398]
[[Category: DNA topoisomerase (ATP-hydrolyzing)]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Tunnicliffe, A.]]
[[Category: Tunnicliffe, A.]]
[[Category: Weston, S A.]]
[[Category: Weston, S A.]]
[[Category: antibiotic]]
[[Category: Antibiotic]]
[[Category: gyrase]]
[[Category: Gyrase]]
[[Category: novobiocin]]
[[Category: Novobiocin]]
[[Category: resistant mutant]]
[[Category: Resistant mutant]]
[[Category: topoisomerase]]
[[Category: Topoisomerase]]
 
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