703DSS: Difference between revisions

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Another way the 5-HT3 receptor has been used in medicine is by aiding in the treatment of substance abuse. When human subjects with an alcohol or morphine addictions were administered a 5-HT3 antagonist, their levels of drug consumption decreased drastically<ref name="thompson" />. However, this decrease was not shown in subjects addicted to psychostimulants like cocaine. Most research done on treatment for addiction is on the level of cognitive behavioral changes implemented by a psychologist. By adding an 5-HT3 antagonist to the treatment plan in addition to cognitive behavioral therapy, the rate of relapse in patients can be predicted to decrease tremendously.

One of the most successful treatments involving 5-HT3 receptors is the treatment of chemotherapy-induced vomiting. The 5-HT3 receptor plays a key role in gag reflex because of the high concentration of this particular receptor in the dorsal vagal complex of the digestive tract, an area responsible for vomit initiation<ref name="hannon">Hannon, J., & Hoyer, D. (2008). Research report: molecular biology of 5-HT receptors. Behavioural Brain Research, 195(Serotonin and cognition: mechanisms and applications), 198-213. doi:10.1016/j.bbr.2008.03.020</ref>. Studies have found that when there is a mutation in the promoter region of the 5-HT3B receptor gene, vomiting was reduced ~~(Thompson & Lummis, 2009)~~. Patients receiving chemotherapy are already subjecting their bodies to an immense amount of stress, so by being able to relieve them of some adverse side-effects, might contribute to an overall better outcome for the patient.

One of the most successful treatments involving 5-HT3 receptors is the treatment of chemotherapy-induced vomiting. The 5-HT3 receptor plays a key role in gag reflex because of the high concentration of this particular receptor in the dorsal vagal complex of the digestive tract, an area responsible for vomit initiation<ref name="hannon">Hannon, J., & Hoyer, D. (2008). Research report: molecular biology of 5-HT receptors. Behavioural Brain Research, 195(Serotonin and cognition: mechanisms and applications), 198-213. doi:10.1016/j.bbr.2008.03.020</ref>. Studies have found that when there is a mutation in the promoter region of the 5-HT3B receptor gene, vomiting was reduced<ref name="thompson" />. Patients receiving chemotherapy are already subjecting their bodies to an immense amount of stress, so by being able to relieve them of some adverse side-effects, might contribute to an overall better outcome for the patient.

The most well studied use of the 5-HT3 receptor is in combating IBS. The 5-HT3 receptor is found in high concentration on the mucosal membrane of the stomach, when this receptor is over activated, it can cause pain in the colon as well as an increased rate in the production of waste. When an antagonist of the receptor was administered to patients with IBS, their symptoms were alleviated ~~(Thompson & Lummis, 2009)~~. This demonstrates the wide variety of possible medical treatments that include the utilization of 5-HT3 receptors and how much more there still is to be discovered.

The most well studied use of the 5-HT3 receptor is in combating IBS. The 5-HT3 receptor is found in high concentration on the mucosal membrane of the stomach, when this receptor is over activated, it can cause pain in the colon as well as an increased rate in the production of waste. When an antagonist of the receptor was administered to patients with IBS, their symptoms were alleviated<ref name="thompson">. This demonstrates the wide variety of possible medical treatments that include the utilization of 5-HT3 receptors and how much more there still is to be discovered.

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 Another way the 5-HT3 receptor has been used in medicine is by aiding in the treatment of substance abuse. When human subjects with an alcohol or morphine addictions were administered a 5-HT3 antagonist, their levels of drug consumption decreased drastically<ref name="thompson" />. However, this decrease was not shown in subjects addicted to psychostimulants like cocaine. Most research done on treatment for addiction is on the level of cognitive behavioral changes implemented by a psychologist. By adding an 5-HT3 antagonist to the treatment plan in addition to cognitive behavioral therapy, the rate of relapse in patients can be predicted to decrease tremendously.
-One of the most successful treatments involving 5-HT3 receptors is the treatment of chemotherapy-induced vomiting. The 5-HT3 receptor plays a key role in gag reflex because of the high concentration of this particular receptor in the dorsal vagal complex of the digestive tract, an area responsible for vomit initiation<ref name="hannon">Hannon, J., & Hoyer, D. (2008). Research report: molecular biology of 5-HT receptors. Behavioural Brain Research, 195(Serotonin and cognition: mechanisms and applications), 198-213. doi:10.1016/j.bbr.2008.03.020</ref>. Studies have found that when there is a mutation in the promoter region of the 5-HT3B receptor gene, vomiting was reduced (Thompson & Lummis, 2009). Patients receiving chemotherapy are already subjecting their bodies to an immense amount of stress, so by being able to relieve them of some adverse side-effects, might contribute to an overall better outcome for the patient.
+One of the most successful treatments involving 5-HT3 receptors is the treatment of chemotherapy-induced vomiting. The 5-HT3 receptor plays a key role in gag reflex because of the high concentration of this particular receptor in the dorsal vagal complex of the digestive tract, an area responsible for vomit initiation<ref name="hannon">Hannon, J., & Hoyer, D. (2008). Research report: molecular biology of 5-HT receptors. Behavioural Brain Research, 195(Serotonin and cognition: mechanisms and applications), 198-213. doi:10.1016/j.bbr.2008.03.020</ref>. Studies have found that when there is a mutation in the promoter region of the 5-HT3B receptor gene, vomiting was reduced<ref name="thompson" />. Patients receiving chemotherapy are already subjecting their bodies to an immense amount of stress, so by being able to relieve them of some adverse side-effects, might contribute to an overall better outcome for the patient.
-The most well studied use of the 5-HT3 receptor is in combating IBS. The 5-HT3 receptor is found in high concentration on the mucosal membrane of the stomach, when this receptor is over activated, it can cause pain in the colon as well as an increased rate in the production of waste. When an antagonist of the receptor was administered to patients with IBS, their symptoms were alleviated (Thompson & Lummis, 2009).  This demonstrates the wide variety of possible medical treatments that include the utilization of 5-HT3 receptors and how much more there still is to be discovered.
+The most well studied use of the 5-HT3 receptor is in combating IBS. The 5-HT3 receptor is found in high concentration on the mucosal membrane of the stomach, when this receptor is over activated, it can cause pain in the colon as well as an increased rate in the production of waste. When an antagonist of the receptor was administered to patients with IBS, their symptoms were alleviated<ref name="thompson">. This demonstrates the wide variety of possible medical treatments that include the utilization of 5-HT3 receptors and how much more there still is to be discovered.