Sandbox8999: Difference between revisions
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{{STRUCTURE_3lvg| PDB=3lvg | SIZE=400| SCENE= |right|CAPTION=Bovine clathrin heavy (grey, green, pink) and light (yellow, magenta, cyan) chains, [[3lvg]] }}'''Clathrin''' originates from the Latin word clāthrātus, meaning “to provide with a lattice”.<ref> Clathrin. (2015). ''Oxford University Press''. Retrieved from http://www.oxforddictionaries.com/us/definition/american_english/clathrin.</ref> Clathrin is a protein involved in receptor-mediated endocytosis.<ref name="harrison"> Harrison, S. C., Kirchhausen, T., & Owen, D. (2014). Molecular structure, function, and dynamics of clathrin-mediated membrane traffic. ''Cold Spring Harbor Perspectives in Biology.'' [http://dx.doi.org/10.1101/cshperspect.a016725 doi: 10.1101/cshperspect.a016725]</ref> The protein was discovered by Barbara Pearse, a biological scientist, in 1975. Clathrin is a protein resembling a triskelion shape and is composed of three heavy chains and three light chains which come together to form a polyhedral lattice similar to a cage.<ref name="harrison" /> The three heavy chains resemble three legs protruding from a center point. Some of the major functions of clathrin include lysosomal targeting, receptor-mediated endocytosis, and organelle biogenesis from the trans-Golgi network.<ref name="wakeham">Wakeham, D. E., et al. (2003). Clathrin self-assembly involves coordinated weak interactions favorable for cellular recognition. ''The Embo Journal.'' [http://dx.doi.org/10.1093/emboj/cdg511 doi: 10.1093/emboj/cdg511]</ref> The polyhedral lattice shape of clathrin largely determines its functionality, in that there are many binding sites for proteins on the heavy chains of the lattice as well.<ref name="ungewickell">Ungewickell, E., & Brandon, D. (1981). Assembly units of clathrin coats. ''Nature, 289'', 420-42. [http://dx.doi.org/10.1038/289420a0 doi: 10.1038/289420a0]</ref> | {{STRUCTURE_3lvg| PDB=3lvg | SIZE=400| SCENE= |right|CAPTION=Bovine clathrin heavy (grey, green, pink) and light (yellow, magenta, cyan) chains, [[3lvg]] }}'''Clathrin''' originates from the Latin word clāthrātus, meaning “to provide with a lattice”.<ref> Clathrin. (2015). ''Oxford University Press''. Retrieved from http://www.oxforddictionaries.com/us/definition/american_english/clathrin.</ref> Clathrin is a protein involved in receptor-mediated endocytosis.<ref name="harrison"> Harrison, S. C., Kirchhausen, T., & Owen, D. (2014). Molecular structure, function, and dynamics of clathrin-mediated membrane traffic. ''Cold Spring Harbor Perspectives in Biology.'' [http://dx.doi.org/10.1101/cshperspect.a016725 doi: 10.1101/cshperspect.a016725]</ref> The protein was discovered by Barbara Pearse, a biological scientist, in 1975.<ref name="pearse">PMID: 1063406</ref> Clathrin is a protein resembling a triskelion shape and is composed of three heavy chains and three light chains which come together to form a polyhedral lattice similar to a cage.<ref name="harrison" /> The three heavy chains resemble three legs protruding from a center point. Some of the major functions of clathrin include lysosomal targeting, receptor-mediated endocytosis, and organelle biogenesis from the trans-Golgi network.<ref name="wakeham">Wakeham, D. E., et al. (2003). Clathrin self-assembly involves coordinated weak interactions favorable for cellular recognition. ''The Embo Journal.'' [http://dx.doi.org/10.1093/emboj/cdg511 doi: 10.1093/emboj/cdg511]</ref> The polyhedral lattice shape of clathrin largely determines its functionality, in that there are many binding sites for proteins on the heavy chains of the lattice as well.<ref name="ungewickell">Ungewickell, E., & Brandon, D. (1981). Assembly units of clathrin coats. ''Nature, 289'', 420-42. [http://dx.doi.org/10.1038/289420a0 doi: 10.1038/289420a0]</ref> | ||
== Structure == | == Structure == | ||
