P.69 Pertactin Structure and Function: Difference between revisions
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==Introduction== | ==Introduction== | ||
Pertactin is a virulence toxin of ''Bordetella parapertussis'' and close relatives, such as ''Bordetella pertussis''. It is an outer surface membrane protein involved in the binding of ''B. parapertussis'' to host cells, which aids the bacteria in infection of host cells with whooping cough. Many of the conserved regions in this protein, such as its passenger and autotransporter domains, contribute directly to the overall virulence and pathogenicity of these organisms. | Pertactin is a virulence toxin of ''Bordetella parapertussis'' and close relatives, such as ''Bordetella pertussis''. It is an outer surface membrane protein involved in the binding of ''B. parapertussis'' to host cells, which aids the bacteria in infection of host cells with whooping cough. Many of the conserved regions in this protein, such as its passenger and autotransporter domains, contribute directly to the overall virulence and pathogenicity of these organisms. | ||
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As a whole, Pertactin and Pertussis toxin are structurally very different. However, amino acid alignments between Pertactin and each of the five subunits of Pertussis toxin reveals that various sections of Pertactin are the same or highly similar to individual subunits of Pertussis toxin ([[Media:Prn1.png | Figure 1]], [[Media:Prn2.png | Figure 2]], [[Media:Prn3.png | Figure 3]], [[Media:Prn4.png | Figure 4]], [[Media:Prn5.png | Figure 5]]). BLAST results also revealed that subunits 4 and 5’s structures consist of an OB fold and a closed or partly open beta barrel.<ref name="CON" /> Similar amino acid sequences, as well as similarities between Pertactin’s beta barrel structure and the beta barrel structures of subunits 4 and 5 may be how Pertactin and Pertussis toxin have similar functions. | As a whole, Pertactin and Pertussis toxin are structurally very different. However, amino acid alignments between Pertactin and each of the five subunits of Pertussis toxin reveals that various sections of Pertactin are the same or highly similar to individual subunits of Pertussis toxin ([[Media:Prn1.png | Figure 1]], [[Media:Prn2.png | Figure 2]], [[Media:Prn3.png | Figure 3]], [[Media:Prn4.png | Figure 4]], [[Media:Prn5.png | Figure 5]]). BLAST results also revealed that subunits 4 and 5’s structures consist of an OB fold and a closed or partly open beta barrel.<ref name="CON" /> Similar amino acid sequences, as well as similarities between Pertactin’s beta barrel structure and the beta barrel structures of subunits 4 and 5 may be how Pertactin and Pertussis toxin have similar functions. | ||
{{:The Structure of Bordetella Pertussis Virulence Factor P.69 Pertactin}} | |||
== References == | == References == | ||
<references/> | <references/> | ||
