User:Michael Adams/Sandbox 1: Difference between revisions
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Figure 1a (Left). Structure of an arginine kinase in substrate-bound form Figure 1b (right). Structure of an AK in an unbound conformation. | Figure 1a (Left). Structure of an arginine kinase in substrate-bound form Figure 1b (right). Structure of an AK in an unbound conformation. | ||
ATP + L-arginine ADP + Nω-phospho-L-arginine | ATP + L-arginine ADP + Nω-phospho-L-arginine | ||
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== Application to the Animal Kingdom == | == Application to the Animal Kingdom == | ||
Arginine Kinase is the individual phosphagen kinase that is found in major invertebrates, such as: arthropods, mollusks, and echinoderms. Most recently, an arginine kinase was purified from a house fly <ref name=wallimann1973 />. This gave Wallimann and Eppenberger the initiative to investigate the arginine kinase in Drosophila melanogaster, also known as a fruit fly | Arginine Kinase is the individual phosphagen kinase that is found in major invertebrates, such as: arthropods, mollusks, and echinoderms. Most recently, an arginine kinase was purified from a house fly <ref name=wallimann1973 />. This gave Wallimann and Eppenberger the initiative to investigate the arginine kinase in Drosophila melanogaster, also known as a fruit fly <ref name=wallimann1973 />. Since the genome and genetic development of Drosophila melanogaster is well understood, this allows for any discoveries made to be easily interpreted. Additionally, further discoveries will help better understand the characteristics of arginine kinase corresponding vertebrate enzyme, creatine kinase <ref name=wallimann1973 />. | ||
Arginine Kinase (AK) is represented by a single gene and the sequence or partial sequence is available from Drosophila, Limulus, lobster, shrimp, and abalone <ref>Wang, Yu-mei E., Pia Esbensen, and David Bentley. "Arginine Kinase Expression and | Arginine Kinase (AK) is represented by a single gene and the sequence or partial sequence is available from Drosophila, Limulus, lobster, shrimp, and abalone <ref>Wang, Yu-mei E., Pia Esbensen, and David Bentley. "Arginine Kinase Expression and | ||
