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| ==Regulation of Anxiety== | | ==Regulation of Anxiety== |
| CB1 receptors are responsible for mediating the anti-anxiety effects of cannabinoids, like THC. In low doses, cannabinoids reduce anxiety; however, high doses of cannabinoids act to increase anxiety <ref name="toxic" />. This is one reason why synthetic cannabinoids like K2, an extremely potent synthetic cannabinoid, produces the harmful side effect of extreme anxiety. | | CB1 receptors are responsible for mediating the anti-anxiety effects of cannabinoids, like THC. In low doses, cannabinoids reduce anxiety; however, high doses of cannabinoids act to increase anxiety <ref name="toxic" />. This is one reason why synthetic cannabinoids like K2, an extremely potent synthetic cannabinoid, produces the harmful side effect of extreme anxiety. |
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| == References == | | == References == |
| <references/>
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| <ref>Mir MD, Arshid, Adebsi Obafemi MD, Amy Young MD, and Colin Kane MD.
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| "Myocardial Infarction Associated With Use of the Synthetic Cannabinoid K@."Pediatrics. Print.</ref>
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| <ref>Lapoint, J. et al. “Severe Toxicity Following Synthetic Cannabinoid Ingestion.” Clinical
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| toxicology (Philadelphia, Pa.) 49.8 (2011): 760–764. PMC. Web. 17 Nov. 2015.</ref>
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| <ref>Svizenska, Ivana, Petr Dubovy, and Alexandra Sulcova. "Cannabinoid Receptors 1 and 2
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| (CB1 and CB2), Their Distribution, Ligands and Functional Involvement in Nervous System Structures — A Short Review." Elsevier B.V. Web. 17 Nov. 2015. <http://www.sciencedirect.com/science/article/pii/S0091305708001743>. </ref>
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| <ref>Domenici, Maria R., Shahnaz C. Azad, Giovanni Marsicano, Anja Schierloh, Carsten T.
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| Wotjak, Hans-Ulrich Dodt, Walter Zieglgansberger, Beat Lutz, and Gerhard Rammes."Cannabinoid Recepter Type 1 Located on Presynaptic Terminals of Principal Neurons in the Forebrain Controls Glutamatergic Synaptic Transmission." The Journal of Neuroscience (2006). Print. </ref>
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| <ref>Albayram, Onder et al. “Role of CB1 Cannabinoid Receptors on GABAergic Neurons in
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| Brain Aging.” Proceedings of the National Academy of Sciences of the United States of America 108.27 (2011): 11256–11261. PMC. Web. 17 Nov. 2015.</ref>
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| <ref>Han, Jing, Philip Kesner, Mathilde Metna-Laurent, Tingting Duan, Lin Xu, Francois Georges,
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| Muriel Koehl, Djoher Nora Abrous, Juan Mendizabal-Zubiaga, Pedro Grandes, Qingsong Liu, Guang Bai, Wei Wang, Lize Xiong, Wei Ren, Giovanni Marsicano, and Xia Zhang. "Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD." Cell: 1039-050. Print. </ref>
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| <ref>Jager, Gerry, and Renger F. Witkamp. "The Endocannabinoid System and Appetite: Relevance
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| for Food Reward." Nutr. Res. Rev. Nutrition Research Reviews: 172-85. Print. </ref>
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| <ref>Fantegrossi, William E. et al. “Distinct Pharmacology and Metabolism of K2 Synthetic
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| Cannabinoids Compared to Δ9-THC: Mechanism Underlying Greater Toxicity?” Life sciences 97.1 (2014): 45–54. PMC. Web. 16 Nov. 2015</ref>
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| <references/> | | <references/> |
