5emv: Difference between revisions
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''' | ==Crystal structure of the palmitoylated human TEAD2 transcription factor== | ||
<StructureSection load='5emv' size='340' side='right' caption='[[5emv]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5emv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EMV FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=P1L:S-PALMITOYL-L-CYSTEINE'>P1L</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5emw|5emw]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5emv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emv OCA], [http://pdbe.org/5emv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5emv RCSB], [http://www.ebi.ac.uk/pdbsum/5emv PDBsum]</span></td></tr> | |||
[[ | </table> | ||
[[ | == Function == | ||
[ | [[http://www.uniprot.org/uniprot/TEAD2_HUMAN TEAD2_HUMAN]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref> | ||
[[ | == References == | ||
[[Category: Cunningham, C | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cunningham, C N]] | |||
[[Category: Dey, A]] | [[Category: Dey, A]] | ||
[[Category: Fairbrother, W J]] | |||
[[Category: Gierke, S]] | [[Category: Gierke, S]] | ||
[[Category: | [[Category: Hannoush, R N]] | ||
[[Category: | [[Category: Murray, J]] | ||
[[Category: Noland, C | [[Category: Noland, C L]] | ||
[[Category: Schnier, P | [[Category: Sagolla, M]] | ||
[[Category: Sandoval, W N]] | |||
[[Category: Schnier, P D]] | |||
[[Category: Palmitoylated protein]] | |||
[[Category: Transcription]] | |||
Revision as of 12:49, 23 December 2015
Crystal structure of the palmitoylated human TEAD2 transcription factor
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