Cullin: Difference between revisions
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'''Cullins''' are hydrophobic scaffold proteins for E3 ubiquitin ligases. They combine with ring box proteins (RBX) to form the CRL complex.<ref>PMID:15688063</ref> The CRL complex is essential in targeting proteins to ubiquitin-mediated destruction. Cullin-1 to 7 are part of the multi-subunit ubiquitin complex. Conjugation of cullin to NEDD8 modulates the activation of the CRL.<br /> | '''Cullins''' are hydrophobic scaffold proteins for E3 ubiquitin ligases. They combine with ring box proteins (RBX) to form the CRL complex.<ref>PMID:15688063</ref> The CRL complex is essential in targeting proteins to ubiquitin-mediated destruction. Cullin-1 to 7 are part of the multi-subunit ubiquitin complex. Conjugation of cullin to NEDD8 modulates the activation of the CRL.<br /> | ||
*'''Cullin-1''' is part of the SCF (Skp-cullin-F-box containing) complex which catalyzes the ubiquitination of proteins.<ref>PMID:11961546</ref><br /> | *'''Cullin-1''' is part of the SCF (Skp-cullin-F-box containing) complex which catalyzes the ubiquitination of proteins.<ref>PMID:11961546</ref><br /> | ||
*'''Cullin-2''' is part of the ECS (Elongin-cullin-SOCS-box) complex.<br /> | *'''Cullin-2''' is part of the ECS (Elongin-cullin-SOCS-box) complex.<ref>PMID:25661653</ref><br /> | ||
*'''Cullin-3''' is part of the BTB-Cul3 complex.<ref>PMID:23349464</ref> <br /> | *'''Cullin-3''' is part of the BTB-Cul3 complex.<ref>PMID:23349464</ref> <br /> | ||
*'''Cullin-4A and 4B''' regulate various processes like DNA repair, chromatin remodeling and mitotic cell cycle.<ref>PMID:22118460</ref><br /> | *'''Cullin-4A and 4B''' regulate various processes like DNA repair, chromatin remodeling and mitotic cell cycle.<ref>PMID:22118460</ref><br /> | ||
*'''Cullin-5''' inhibits cellular proliferation.<ref>PMID:18805092</ref><br /> | *'''Cullin-5''' inhibits cellular proliferation.<ref>PMID:18805092</ref><br /> | ||
*'''Cullin-7''' is a core component of a complex which mediates ubiquitination of target proteins.<ref>PMID:17298945</ref><br /> | |||
</StructureSection> | </StructureSection> | ||
