4qrb: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation==

~~The entry~~ 4qrb is ~~ON HOLD until Dec 23 2016~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4qrb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QRB OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QRB FirstGlance].

~~Authors~~: ~~Gokulan~~, K., ~~Varughese~~, K.I., ~~Center for Structural Genomics of Infectious Diseases (CSGID)~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4qr7|4qr7]], [[4qra|4qra]]</td></tr>

~~Description~~: ~~Structure and specificity~~ of L-D-~~Transpeptidase from Mycobacterium tuberculosis~~ and ~~antibiotic resistance~~: ~~Calcium binding promotes dimer formation~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qrb OCA], [http://pdbe.org/4qrb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qrb RCSB], [http://www.ebi.ac.uk/pdbsum/4qrb PDBsum]</td></tr>

~~[[Category: Unreleased Structures]]~~

</table>

[[Category: ~~Varughese, K.I~~]]

== Function ==

[[http://www.uniprot.org/uniprot/LDT2_MYCTU LDT2_MYCTU]] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.<ref>PMID:24041897</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Structural genomic]]

[[Category: Gokulan, K]]

[[Category: ~~Center For Structural Genomics Of Infectious Diseases (~~Csgid)]]

[[Category: Varughese, K I]]

[[Category: Bacterial cell wall periplasmic region]]

[[Category: Beta-lactamase]]

[[Category: Csgid]]

[[Category: D-d-transpeptidase]]

[[Category: Enzyme function initiative]]

[[Category: Hydrolase]]

[[Category: Imipenem]]

[[Category: L-d-transpeptidase]]

[[Category: Meropenem]]

[[Category: Peptide cross linkage]]

[[Category: Peptidoglycan]]

[[Category: Peptidoglycan stem]]

[[Category: Single anomalous diffraction]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation==
+<StructureSection load='4qrb' size='340' side='right' caption='[[4qrb]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
-The entry 4qrb is ON HOLD  until Dec 23 2016
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4qrb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QRB FirstGlance]. <br>
-Authors: Gokulan, K., Varughese, K.I., Center for Structural Genomics of Infectious Diseases (CSGID)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qr7|4qr7]], [[4qra|4qra]]</td></tr>
-Description: Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qrb OCA], [http://pdbe.org/4qrb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qrb RCSB], [http://www.ebi.ac.uk/pdbsum/4qrb PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Varughese, K.I]]
+== Function ==
+[[http://www.uniprot.org/uniprot/LDT2_MYCTU LDT2_MYCTU]] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.<ref>PMID:24041897</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Structural genomic]]
 [[Category: Gokulan, K]]
-[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
+[[Category: Varughese, K I]]
+[[Category: Bacterial cell wall periplasmic region]]
+[[Category: Beta-lactamase]]
+[[Category: Csgid]]
+[[Category: D-d-transpeptidase]]
+[[Category: Enzyme function initiative]]
+[[Category: Hydrolase]]
+[[Category: Imipenem]]
+[[Category: L-d-transpeptidase]]
+[[Category: Meropenem]]
+[[Category: Peptide cross linkage]]
+[[Category: Peptidoglycan]]
+[[Category: Peptidoglycan stem]]
+[[Category: Single anomalous diffraction]]