5ad2: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 5ad2 is ON HOLD  until Paper Publication
==Bivalent binding to BET bromodomains==
 
<StructureSection load='5ad2' size='340' side='right' caption='[[5ad2]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
Authors: Waring, M.J., Chen, H., Rabow, A.A., Walker, G., Bobby, R., Boiko, S., Bradbury, R.H., Callis, R., Dale, I., Daniels, D., Flavell, L., Holdgate, G., Jowitt, T.A., Kikhney, A., McAlister, M., Ogg, D., Patel, J., Petteruti, P., Robb, G.R., Robers, M., Stratton, N., Svergun, D.I., Wang, W., Whittaker, D.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5ad2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AD2 FirstGlance]. <br>
Description: Bivalent binding to BET bromodomains
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ETU:(3R)-4-(2-{4-[1-(3-CHLORO[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)-4-PIPERIDINYL]PHENOXY}ETHYL)-1,3-DIMETHYL-2-PIPERAZINONE'>ETU</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ad3|5ad3]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ad2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ad2 OCA], [http://pdbe.org/5ad2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ad2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ad2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ad2 ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bobby, R]]
[[Category: Boiko, S]]
[[Category: Bradbury, R H]]
[[Category: Callis, R]]
[[Category: Chen, H]]
[[Category: Dale, I]]
[[Category: Daniels, D]]
[[Category: Flavell, L]]
[[Category: Holdgate, G]]
[[Category: Jowitt, T A]]
[[Category: Kikhney, A]]
[[Category: McAlister, M]]
[[Category: Ogg, D]]
[[Category: Ogg, D]]
[[Category: Patel, J]]
[[Category: Petteruti, P]]
[[Category: Rabow, A A]]
[[Category: Robb, G R]]
[[Category: Robers, M]]
[[Category: Stratton, N]]
[[Category: Svergun, D I]]
[[Category: Walker, G]]
[[Category: Walker, G]]
[[Category: Wang, W]]
[[Category: Wang, W]]
[[Category: Rabow, A.A]]
[[Category: Waring, M J]]
[[Category: Stratton, N]]
[[Category: Robers, M]]
[[Category: Petteruti, P]]
[[Category: Dale, I]]
[[Category: Chen, H]]
[[Category: Robb, G.R]]
[[Category: Jowitt, T.A]]
[[Category: Waring, M.J]]
[[Category: Callis, R]]
[[Category: Whittaker, D]]
[[Category: Whittaker, D]]
[[Category: Svergun, D.I]]
[[Category: Transcription]]
[[Category: Flavell, L]]
[[Category: Patel, J]]
[[Category: Mcalister, M]]
[[Category: Bobby, R]]
[[Category: Kikhney, A]]
[[Category: Holdgate, G]]
[[Category: Bradbury, R.H]]
[[Category: Boiko, S]]
[[Category: Daniels, D]]
Retrieved from "https://proteopedia.org/5ad2"