5awc: Difference between revisions
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==Crystal structure of human TLR8 in complex with MB-564== | |||
<StructureSection load='5awc' size='340' side='right' caption='[[5awc]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5awc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AWC FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=M4D:5-(4-AZANYLBUTYL)-3-PENTYL-QUINOLIN-2-AMINE'>M4D</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5awa|5awa]], [[5awb|5awb]], [[5awd|5awd]]</td></tr> | ||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5awc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5awc OCA], [http://pdbe.org/5awc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5awc RCSB], [http://www.ebi.ac.uk/pdbsum/5awc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5awc ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ohto, U]] | [[Category: Ohto, U]] | ||
[[Category: Shimizu, T]] | [[Category: Shimizu, T]] | ||
[[Category: Tanji, H]] | |||
[[Category: Adjuvant]] | |||
[[Category: Glycosylation]] | |||
[[Category: Immune system]] | |||
[[Category: Linnate immunity]] | |||
[[Category: Tlr8]] | |||
[[Category: Vaccine adjuvant]] | |||
Revision as of 15:25, 26 July 2016
Crystal structure of human TLR8 in complex with MB-564
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