5bnh: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5bnh ~~is ON HOLD until Paper Publication~~

==Crystal structure of the HLTF HIRAN domain with a ssDNA fragment==

~~Authors~~: ~~Neculai, D~~., ~~Walker~~, J.R., ~~Weigelt~~, J., ~~Bountra, C~~.~~, Edwards, A~~.M., ~~Arrowsmith, C~~.H.~~, Dhe-Paganon, S~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5bnh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BNH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BNH FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of the ~~HLTF HIRAN domain with~~ a ~~ssDNA fragment~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bnh OCA], [http://pdbe.org/5bnh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bnh RCSB], [http://www.ebi.ac.uk/pdbsum/5bnh PDBsum]</span></td></tr>

[[Category: ~~Arrowsmith~~, C.H]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/HLTF_HUMAN HLTF_HUMAN]] Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.<ref>PMID:10391891</ref> <ref>PMID:18316726</ref> <ref>PMID:18719106</ref> <ref>PMID:7876228</ref> <ref>PMID:8672239</ref> <ref>PMID:9126292</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Dhe-Paganon, S]]

[[Category: Edwards, A M]]

[[Category: Neculai, D]]

~~[[Category: Edwards, A.M]]~~

[[Category: Walker, J R]]

[[Category: Walker, J.R]]

~~[[Category: Dhe-Paganon, S~~]]

[[Category: Weigelt, J]]

[[Category: ~~Bountra, C~~]]

[[Category: Dna binding domain]]

[[Category: Dna binding protein-dna complex]]

[[Category: Dna damage]]

[[Category: Dna recognition]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5bnh is ON HOLD  until Paper Publication
+==Crystal structure of the HLTF HIRAN domain with a ssDNA fragment==
+<StructureSection load='5bnh' size='340' side='right' caption='[[5bnh]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-Authors: Neculai, D., Walker, J.R., Weigelt, J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Dhe-Paganon, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5bnh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BNH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BNH FirstGlance]. <br>
-Description: Crystal structure of the HLTF HIRAN domain with a ssDNA fragment
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bnh OCA], [http://pdbe.org/5bnh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bnh RCSB], [http://www.ebi.ac.uk/pdbsum/5bnh PDBsum]</span></td></tr>
-[[Category: Arrowsmith, C.H]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HLTF_HUMAN HLTF_HUMAN]] Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.<ref>PMID:10391891</ref> <ref>PMID:18316726</ref> <ref>PMID:18719106</ref> <ref>PMID:7876228</ref> <ref>PMID:8672239</ref> <ref>PMID:9126292</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Dhe-Paganon, S]]
+[[Category: Edwards, A M]]
 [[Category: Neculai, D]]
-[[Category: Edwards, A.M]]
+[[Category: Walker, J R]]
-[[Category: Walker, J.R]]
-[[Category: Dhe-Paganon, S]]
 [[Category: Weigelt, J]]
-[[Category: Bountra, C]]
+[[Category: Dna binding domain]]
+[[Category: Dna binding protein-dna complex]]
+[[Category: Dna damage]]
+[[Category: Dna recognition]]