5c3f: Difference between revisions
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==Crystal structure of Mcl-1 bound to BID-MM== | |||
<StructureSection load='5c3f' size='340' side='right' caption='[[5c3f]], [[Resolution|resolution]] 1.43Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5c3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C3F FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
[[ | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3f OCA], [http://pdbe.org/5c3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c3f RCSB], [http://www.ebi.ac.uk/pdbsum/5c3f PDBsum]</span></td></tr> | |||
[[Category: Edwards, T | </table> | ||
[[Category: | == Function == | ||
[[Category: Pask, C | [[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Edwards, T A]] | |||
[[Category: Miles, J A]] | |||
[[Category: Pask, C M]] | |||
[[Category: Rodriguez-Marin, S]] | [[Category: Rodriguez-Marin, S]] | ||
[[Category: Rowell, P]] | [[Category: Rowell, P]] | ||
[[Category: Warriner, S L]] | |||
[[Category: Wilson, A J]] | |||
[[Category: Yeo, D J]] | |||
[[Category: Apoptosis]] | |||
[[Category: Bcl-2 family]] | |||
[[Category: Bh3]] | |||
[[Category: Complex]] | |||
[[Category: Stapled peptide]] | |||
Revision as of 18:41, 12 May 2016
Crystal structure of Mcl-1 bound to BID-MM
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