5cs8: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==

~~The entry~~ 5cs8 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5cs8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS8 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CS8 FirstGlance].

~~Authors~~: ~~Zhang~~, Y., ~~Song~~, M., ~~Liu~~, Z., ~~Xue~~, X., Xu, Y.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EB8:METHYL+2-[(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)SULFAMOYL]BENZOATE'>EB8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>

~~Description~~: ~~Crystal Structure of the first bromodomain of human~~ BRD4 in ~~complex~~ with ~~benzo~~[cd]~~indol-2~~(1H)~~-one ligand~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs8 OCA], [http://pdbe.org/5cs8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs8 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs8 PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

== Function ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Liu, Z]]

[[Category: Song, M]]

[[Category: Xu, Y]]

[[Category: Xue, X]]

[[Category: Zhang, Y]]

[[Category: ~~Xue, X~~]]

[[Category: Brd4]]

[[Category: ~~Liu, Z~~]]

[[Category: Bromodomain]]

[[Category: ~~Song, M~~]]

[[Category: Bromodomain binding inhibitor]]

[[Category: Dna binding protein-dna binding protein inhibitor complex]]

[[Category: Four alpha helice]]

[[Category: Inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand==
+<StructureSection load='5cs8' size='340' side='right' caption='[[5cs8]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
-The entry 5cs8 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5cs8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CS8 FirstGlance]. <br>
-Authors: Zhang, Y., Song, M., Liu, Z., Xue, X., Xu, Y.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB8:METHYL+2-[(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)SULFAMOYL]BENZOATE'>EB8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cp5|5cp5]], [[5cpe|5cpe]], [[5coi|5coi]], [[5cqt|5cqt]], [[5crm|5crm]], [[5crz|5crz]], [[5ctl|5ctl]]</td></tr>
-Description: Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs8 OCA], [http://pdbe.org/5cs8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs8 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs8 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Liu, Z]]
+[[Category: Song, M]]
 [[Category: Xu, Y]]
+[[Category: Xue, X]]
 [[Category: Zhang, Y]]
-[[Category: Xue, X]]
+[[Category: Brd4]]
-[[Category: Liu, Z]]
+[[Category: Bromodomain]]
-[[Category: Song, M]]
+[[Category: Bromodomain binding inhibitor]]
+[[Category: Dna binding protein-dna binding protein inhibitor complex]]
+[[Category: Four alpha helice]]
+[[Category: Inhibitor complex]]