5cyp: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5cyp is ~~ON HOLD until Jul 30 2017~~

==GTPase domain of Septin 9 in complex with GTP-gamma-S==

~~Authors~~: ~~Matos~~, S.S., ~~Leonardo, D~~.A., ~~Pereira~~, H.M., ~~Araujo, A~~.P.U., ~~Garratt, R~~.C.

== Structural highlights ==

<table><tr><td colspan='2'>[[5cyp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CYP OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CYP FirstGlance].

~~Description~~: ~~GTPase domain of Septin 9~~ in ~~complex with GTP~~-~~gamma~~-S

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4yqf|4yqf]], [[5cyo|5cyo]]</td></tr>

[[Category: ~~Leonardo~~, D.A]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cyp OCA], [http://pdbe.org/5cyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cyp RCSB], [http://www.ebi.ac.uk/pdbsum/5cyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cyp ProSAT]</td></tr>

[[Category: Garratt, R.C]]

</table>

[[Category: ~~Pereira~~, ~~H.M~~]]

== Disease ==

[[Category: ~~Araujo~~, A~~.P.U~~]]

[[http://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN]] Neuralgic amyotrophy. A chromosomal aberration involving SEPT9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with KMT2A/MLL1.<ref>PMID:10339604</ref> The disease is caused by mutations affecting the gene represented in this entry.

[[Category: Matos, S.S]]

== Function ==

[[http://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

== References ==

__TOC__

</StructureSection>

[[Category: Araujo, A P.U]]

[[Category: Garratt, R C]]

[[Category: Horjales, E]]

[[Category: Leonardo, D A]]

[[Category: Matos, S S]]

[[Category: Pereira, H M]]

[[Category: Hydrolase]]

[[Category: Septin 9 gtpase domain]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5cyp is ON HOLD  until Jul 30 2017
+==GTPase domain of Septin 9 in complex with GTP-gamma-S==
+<StructureSection load='5cyp' size='340' side='right' caption='[[5cyp]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
-Authors: Matos, S.S., Leonardo, D.A., Pereira, H.M., Araujo, A.P.U., Garratt, R.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5cyp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CYP FirstGlance]. <br>
-Description: GTPase domain of Septin 9 in complex with GTP-gamma-S
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yqf|4yqf]], [[5cyo|5cyo]]</td></tr>
-[[Category: Leonardo, D.A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cyp OCA], [http://pdbe.org/5cyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cyp RCSB], [http://www.ebi.ac.uk/pdbsum/5cyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cyp ProSAT]</span></td></tr>
-[[Category: Garratt, R.C]]
+</table>
-[[Category: Pereira, H.M]]
+== Disease ==
-[[Category: Araujo, A.P.U]]
+[[http://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN]] Neuralgic amyotrophy. A chromosomal aberration involving SEPT9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with KMT2A/MLL1.<ref>PMID:10339604</ref>   The disease is caused by mutations affecting the gene represented in this entry.
-[[Category: Matos, S.S]]
+== Function ==
+[[http://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Araujo, A P.U]]
+[[Category: Garratt, R C]]
+[[Category: Horjales, E]]
+[[Category: Leonardo, D A]]
+[[Category: Matos, S S]]
+[[Category: Pereira, H M]]
+[[Category: Hydrolase]]
+[[Category: Septin 9 gtpase domain]]