5czm: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5czm ~~is ON HOLD until Paper Publication~~

==Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470==

~~Authors~~: ~~Rouanet~~-~~Mehouas, C~~., ~~Roselia~~, L., ~~Devel~~, L., ~~Dive~~, V., ~~Stura~~, E.A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5czm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CZM OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CZM FirstGlance].

~~Description~~: ~~Crystal structure of~~ a ~~mutated catalytic domain of Human MMP12 in complex~~ with ~~RXP470~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=R47:N-[(2S)-3-[(S)-(4-BROMOPHENYL)(HYDROXY)PHOSPHORYL]-2-{[3-(3-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}PROPANOYL]-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMINE'>R47</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5czm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5czm OCA], [http://pdbe.org/5czm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5czm RCSB], [http://www.ebi.ac.uk/pdbsum/5czm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5czm ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

__TOC__

</StructureSection>

[[Category: Macrophage elastase]]

[[Category: Devel, L]]

[[Category: Dive, V]]

[[Category: Roselia, L]]

~~[[Category: Devel, L]]~~

[[Category: Rouanet-Mehouas, C]]

[[Category: Stura, E.A]]

[[Category: Stura, E A]]

[[Category: Human]]

[[Category: Hydrolase]]

[[Category: Macrophage]]

[[Category: Matrix]]

[[Category: Metallo elastase]]

[[Category: Mmp12]]

[[Category: Rxp470]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5czm is ON HOLD  until Paper Publication
+==Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470==
+<StructureSection load='5czm' size='340' side='right' caption='[[5czm]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-Authors: Rouanet-Mehouas, C., Roselia, L., Devel, L., Dive, V., Stura, E.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5czm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CZM FirstGlance]. <br>
-Description: Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=R47:N-[(2S)-3-[(S)-(4-BROMOPHENYL)(HYDROXY)PHOSPHORYL]-2-{[3-(3-CHLOROBIPHENYL-4-YL)-1,2-OXAZOL-5-YL]METHYL}PROPANOYL]-L-ALPHA-GLUTAMYL-L-ALPHA-GLUTAMINE'>R47</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5czm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5czm OCA], [http://pdbe.org/5czm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5czm RCSB], [http://www.ebi.ac.uk/pdbsum/5czm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5czm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
+__TOC__
+</StructureSection>
+[[Category: Macrophage elastase]]
+[[Category: Devel, L]]
 [[Category: Dive, V]]
 [[Category: Roselia, L]]
-[[Category: Devel, L]]
 [[Category: Rouanet-Mehouas, C]]
-[[Category: Stura, E.A]]
+[[Category: Stura, E A]]
+[[Category: Human]]
+[[Category: Hydrolase]]
+[[Category: Macrophage]]
+[[Category: Matrix]]
+[[Category: Metallo elastase]]
+[[Category: Mmp12]]
+[[Category: Rxp470]]