5d8f: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5d8f is ~~ON HOLD until Paper Publication~~

==crystal structure of SSB and ssDNA complex from homo sapiens==

~~Authors~~: Li, Y.H., ~~Gao~~, Z.Q., ~~Dong~~, Y.H.

== Structural highlights ==

<table><tr><td colspan='2'>[[5d8f]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D8F OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D8F FirstGlance].

~~Description~~: ~~crystal structure~~ of ~~SSB~~ and ~~ssDNA~~ complex ~~from homo sapiens~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5d8e|5d8e]]</td></tr>

[[Category: Gao, Z.Q]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d8f OCA], [http://pdbe.org/5d8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d8f RCSB], [http://www.ebi.ac.uk/pdbsum/5d8f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d8f ProSAT]</td></tr>

[[Category: ~~Dong~~, Y.H]]

</table>

[[Category: ~~Li, Y.H~~]]

== Function ==

[[http://www.uniprot.org/uniprot/SOSB1_HUMAN SOSB1_HUMAN]] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:18449195</ref> <ref>PMID:19605351</ref> <ref>PMID:19683501</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Dong, Y H]]

[[Category: Gao, Z Q]]

[[Category: Li, Y H]]

[[Category: Dna binding protein-dna complex]]

[[Category: Single-strand dna binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5d8f is ON HOLD  until Paper Publication
+==crystal structure of SSB and ssDNA complex from homo sapiens==
+<StructureSection load='5d8f' size='340' side='right' caption='[[5d8f]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-Authors: Li, Y.H., Gao, Z.Q., Dong, Y.H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5d8f]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D8F FirstGlance]. <br>
-Description: crystal structure of SSB and ssDNA complex from homo sapiens
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d8e|5d8e]]</td></tr>
-[[Category: Gao, Z.Q]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d8f OCA], [http://pdbe.org/5d8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d8f RCSB], [http://www.ebi.ac.uk/pdbsum/5d8f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d8f ProSAT]</span></td></tr>
-[[Category: Dong, Y.H]]
+</table>
-[[Category: Li, Y.H]]
+== Function ==
+[[http://www.uniprot.org/uniprot/SOSB1_HUMAN SOSB1_HUMAN]] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:18449195</ref> <ref>PMID:19605351</ref> <ref>PMID:19683501</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Dong, Y H]]
+[[Category: Gao, Z Q]]
+[[Category: Li, Y H]]
+[[Category: Dna binding protein-dna complex]]
+[[Category: Single-strand dna binding]]