5de4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5de4 ~~is ON HOLD until Paper Publication~~

==Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-fluorophenyl-ACEPC==

~~Authors~~: ~~Mou, T~~.-C., ~~Conti~~, P., ~~Pinto~~, A., ~~Tamborini~~, L., ~~Sprang~~, S.R., ~~Hansen, K~~.B.

== Structural highlights ==

<table><tr><td colspan='2'>[[5de4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DE4 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DE4 FirstGlance].

~~Description~~: ~~Crystal structure of GluN1~~/~~GluN2A~~ NMDA receptor ~~agonist binding domains with~~ glycine and ~~antagonist, 4~~-~~fluorophenyl~~-~~ACEPC~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=5DZ:5-[(2R)-2-AMINO-2-CARBOXYETHYL]-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC+ACID'>5DZ</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5ddn|5ddn]], [[5ddx|5ddx]], [[5dex|5dex]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5de4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5de4 OCA], [http://pdbe.org/5de4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5de4 RCSB], [http://www.ebi.ac.uk/pdbsum/5de4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5de4 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> [[http://www.uniprot.org/uniprot/NMDE1_RAT NMDE1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.

== References ==

__TOC__

</StructureSection>

[[Category: Conti, P]]

[[Category: Hansen, K B]]

[[Category: Mou, T C]]

[[Category: Pinto, A]]

[[Category: Sprang, S R]]

[[Category: Tamborini, L]]

[[Category: ~~Conti, P~~]]

[[Category: Antagonist]]

[[Category: ~~Hansen, K.B~~]]

[[Category: Nmda receptor]]

[[Category: ~~Sprang, S.R~~]]

[[Category: Receptor]]

[[Category: ~~Mou, T.-C~~]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5de4 is ON HOLD  until Paper Publication
+==Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-fluorophenyl-ACEPC==
+<StructureSection load='5de4' size='340' side='right' caption='[[5de4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: Mou, T.-C., Conti, P., Pinto, A., Tamborini, L., Sprang, S.R., Hansen, K.B.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5de4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DE4 FirstGlance]. <br>
-Description: Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-fluorophenyl-ACEPC
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5DZ:5-[(2R)-2-AMINO-2-CARBOXYETHYL]-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC+ACID'>5DZ</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ddn|5ddn]], [[5ddx|5ddx]], [[5dex|5dex]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5de4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5de4 OCA], [http://pdbe.org/5de4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5de4 RCSB], [http://www.ebi.ac.uk/pdbsum/5de4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5de4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref>  [[http://www.uniprot.org/uniprot/NMDE1_RAT NMDE1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Conti, P]]
+[[Category: Hansen, K B]]
+[[Category: Mou, T C]]
 [[Category: Pinto, A]]
+[[Category: Sprang, S R]]
 [[Category: Tamborini, L]]
-[[Category: Conti, P]]
+[[Category: Antagonist]]
-[[Category: Hansen, K.B]]
+[[Category: Nmda receptor]]
-[[Category: Sprang, S.R]]
+[[Category: Receptor]]
-[[Category: Mou, T.-C]]
+[[Category: Transport protein]]