5dqc: Difference between revisions
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==Co-crystal of BACE1 with compound 0211== | |||
<StructureSection load='5dqc' size='340' side='right' caption='[[5dqc]], [[Resolution|resolution]] 2.47Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5dqc]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DQC FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5E7:N-[(2S,3R)-3-HYDROXY-4-({(2S,3S)-3-HYDROXY-1-[(2-METHYLPROPYL)AMINO]-1-OXOBUTAN-2-YL}AMINO)-1-PHENYLBUTAN-2-YL]-5-[METHYL(METHYLSULFONYL)AMINO]-N-[(1R)-1-PHENYLETHYL]BENZENE-1,3-DICARBOXAMIDE'>5E7</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | ||
[[Category: Ghosh, A | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dqc OCA], [http://pdbe.org/5dqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dqc RCSB], [http://www.ebi.ac.uk/pdbsum/5dqc PDBsum]</span></td></tr> | ||
[[Category: Rao, K | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Memapsin 2]] | |||
[[Category: Bhavanam, S R]] | |||
[[Category: Cardenas, E L]] | |||
[[Category: Downs, D]] | |||
[[Category: Ghosh, A K]] | |||
[[Category: Huang, X]] | |||
[[Category: Mescar, A D]] | |||
[[Category: Rao, K V]] | |||
[[Category: Tang, J]] | [[Category: Tang, J]] | ||
[[Category: Yen, T | [[Category: Yen, T C]] | ||
[[Category: | [[Category: Alzheimer's disease]] | ||
[[Category: | [[Category: B-secretase]] | ||
[[Category: | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: | [[Category: Inhibitor]] | ||
Revision as of 02:53, 21 February 2016
Co-crystal of BACE1 with compound 0211
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