5e1a: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5e1a is ~~ON HOLD until Paper Publication~~

==Structure of KcsA with L24C/R117C mutations==

~~Authors~~: ~~Upadhyay~~, V., ~~Kim~~, D.M., ~~Nimigean~~, C.M.

== Structural highlights ==

<table><tr><td colspan='2'>[[5e1a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E1A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E1A FirstGlance]. <br>

~~Description~~: ~~Structure of KcsA with L24C~~/~~R117C mutations~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e1a OCA], [http://pdbe.org/5e1a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e1a RCSB], [http://www.ebi.ac.uk/pdbsum/5e1a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e1a ProSAT]</span></td></tr>

[[Category: Kim, D.M]]

</table>

[[Category: Nimigean, C.M]]

== Function ==

[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Mus musculus]]

[[Category: Kim, D M]]

[[Category: Nimigean, C M]]

[[Category: Upadhyay, V]]

[[Category: Kcsa]]

[[Category: Metal transport]]

[[Category: Mutation]]

[[Category: Potassium channel]]

[[Category: Proton]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5e1a is ON HOLD  until Paper Publication
+==Structure of KcsA with L24C/R117C mutations==
+<StructureSection load='5e1a' size='340' side='right' caption='[[5e1a]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-Authors: Upadhyay, V., Kim, D.M., Nimigean, C.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5e1a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E1A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E1A FirstGlance]. <br>
-Description: Structure of KcsA with L24C/R117C mutations
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e1a OCA], [http://pdbe.org/5e1a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e1a RCSB], [http://www.ebi.ac.uk/pdbsum/5e1a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e1a ProSAT]</span></td></tr>
-[[Category: Kim, D.M]]
+</table>
-[[Category: Nimigean, C.M]]
+== Function ==
+[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Mus musculus]]
+[[Category: Kim, D M]]
+[[Category: Nimigean, C M]]
 [[Category: Upadhyay, V]]
+[[Category: Kcsa]]
+[[Category: Metal transport]]
+[[Category: Mutation]]
+[[Category: Potassium channel]]
+[[Category: Proton]]