5exk: Difference between revisions
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==Crystal structure of M. tuberculosis lipoyl synthase with 6-thiooctanoyl peptide intermediate== | |||
<StructureSection load='5exk' size='340' side='right' caption='[[5exk]], [[Resolution|resolution]] 1.86Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5exk]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EXK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5AD:5-DEOXYADENOSINE'>5AD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=XOK:(2~{S})-2-AZANYL-6-[[(6~{S})-6-SULFANYLOCTANOYL]AMINO]HEXANOIC+ACID'>XOK</scene></td></tr> | ||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5exi|5exi]], [[5exj|5exj]]</td></tr> | ||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lipoyl_synthase Lipoyl synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.8 2.8.1.8] </span></td></tr> | ||
[[Category: Lanz, N | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5exk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5exk OCA], [http://pdbe.org/5exk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5exk RCSB], [http://www.ebi.ac.uk/pdbsum/5exk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5exk ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [[http://www.uniprot.org/uniprot/LIPA_MYCTU LIPA_MYCTU]] Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Lipoyl synthase]] | |||
[[Category: Booker, S J]] | |||
[[Category: Drennan, C L]] | |||
[[Category: Goldman, P J]] | |||
[[Category: Lanz, N D]] | |||
[[Category: Lee, K H]] | |||
[[Category: McLaughlin, M I]] | |||
[[Category: Adomet radical]] | |||
[[Category: Auxiliary iron-sulfur cluster]] | |||
[[Category: Radical sam]] | |||
[[Category: Sulfur insertion]] | |||
[[Category: Transferase]] | |||
Revision as of 16:23, 10 August 2016
Crystal structure of M. tuberculosis lipoyl synthase with 6-thiooctanoyl peptide intermediate
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