5fpu: Difference between revisions
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''' | ==Crystal structure of human JARID1B in complex with GSKJ1== | ||
<StructureSection load='5fpu' size='340' side='right' caption='[[5fpu]], [[Resolution|resolution]] 2.24Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5fpu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FPU FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=URY:3-[[2-PYRIDIN-2-YL-6-(1,2,4,5-TETRAHYDRO-3-BENZAZEPIN-3-YL)PYRIMIDIN-4-YL]AMINO]PROPANOIC+ACID'>URY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fpl|5fpl]], [[5fpv|5fpv]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpu OCA], [http://pdbe.org/5fpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fpu RCSB], [http://www.ebi.ac.uk/pdbsum/5fpu PDBsum]</span></td></tr> | |||
[[ | </table> | ||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
[[Category: | [[Category: Delft, F von]] | ||
[[Category: Edwards, A]] | |||
[[Category: Gileadi, C]] | [[Category: Gileadi, C]] | ||
[[Category: Johansson, C]] | |||
[[Category: Nowak, R]] | |||
[[Category: Oppermann, U]] | [[Category: Oppermann, U]] | ||
[[Category: Srikannathasan, V]] | [[Category: Srikannathasan, V]] | ||
[[Category: Lysine-specific demethylase 5b]] | |||
[[Category: Transcription]] | |||
Revision as of 20:37, 13 January 2016
Crystal structure of human JARID1B in complex with GSKJ1
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