Complexin

spinqualitylabelsall models Human complexin (magenta) as part of the SNARE complex (VAMP2 - cyan; syntaxin - green; SNAP25 (pink and yellow) (PDB entry 3rk3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Complexin (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vesicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vesicle fusion while in another conformation it releases the SNARE complex allowing fusion. Structural highlights CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin (PDB entry 3rk3).

3D structures of complexin

Updated on 15-April-2018

3rk3 – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat

3rk3, 3rl0 - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human

5w5c, 5w5d - CPLX + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin

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Michal Harel, Alexander Berchansky