Defensin: Difference between revisions
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<StructureSection load='2pm4' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''> | <StructureSection load='2pm4' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''> | ||
__TOC__ | |||
== Function == | == Function == | ||
'''Defensins''' (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF contains 6-8 conserved cysteine residues. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients.<ref>PMID: | '''Defensins''' (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF are found in cells of the immune system. DEF contains 6-8 conserved cysteine residues. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients thus killing them.<ref>PMID:8528769</ref> For details on plant DEF see [[Plant defensin]]. | ||
== Relevance == | == Relevance == | ||
There is increase in α-DEF in chronic inflammations and several cancers. | There is increase in α-DEF in chronic inflammations and several cancers. DEF-mimetics are developed as antibiotics. | ||
== Disease == | |||
Overexpression of α-defensin is seen in chronic inflammation, several cancers and in T-cells of schizophrenia patients. | |||
</StructureSection> | </StructureSection> | ||
==3D structures of defensin== | ==3D structures of defensin== | ||
