5f4e: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5f4e is ~~ON HOLD until Paper Publication~~

==Crystal structure of the human sperm Izumo1 and egg Juno complex==

~~Authors~~: ~~Aydin~~, H., ~~Sultana~~, A., ~~Lee~~, J.E.

== Structural highlights ==

<table><tr><td colspan='2'>[[5f4e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F4E OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F4E FirstGlance].

~~Description~~: ~~Membrane~~-~~bound complex structure~~ of a ~~human glycoprotein~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5f4q|5f4q]], [[5f4t|5f4t]], [[5f4v|5f4v]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f4e OCA], [http://pdbe.org/5f4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f4e RCSB], [http://www.ebi.ac.uk/pdbsum/5f4e PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/IZUM1_HUMAN IZUM1_HUMAN]] Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.<ref>PMID:15759005</ref> [[http://www.uniprot.org/uniprot/JUNO_HUMAN JUNO_HUMAN]] Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.[UniProtKB:Q9EQF4]

== References ==

__TOC__

</StructureSection>

[[Category: Aydin, H]]

[[Category: Lee, J E]]

[[Category: Sultana, A]]

[[Category: ~~Aydin, H~~]]

[[Category: Cell adhesion]]

[[Category: ~~Lee, J.E~~]]

[[Category: Complex]]

[[Category: Cysteine-rich]]

[[Category: Glycoprotein]]

[[Category: Membrane-bound]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5f4e is ON HOLD  until Paper Publication
+==Crystal structure of the human sperm Izumo1 and egg Juno complex==
+<StructureSection load='5f4e' size='340' side='right' caption='[[5f4e]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: Aydin, H., Sultana, A., Lee, J.E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5f4e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F4E FirstGlance]. <br>
-Description: Membrane-bound complex structure of a human glycoprotein
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f4q|5f4q]], [[5f4t|5f4t]], [[5f4v|5f4v]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f4e OCA], [http://pdbe.org/5f4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f4e RCSB], [http://www.ebi.ac.uk/pdbsum/5f4e PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/IZUM1_HUMAN IZUM1_HUMAN]] Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.<ref>PMID:15759005</ref>  [[http://www.uniprot.org/uniprot/JUNO_HUMAN JUNO_HUMAN]] Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.[UniProtKB:Q9EQF4]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Aydin, H]]
+[[Category: Lee, J E]]
 [[Category: Sultana, A]]
-[[Category: Aydin, H]]
+[[Category: Cell adhesion]]
-[[Category: Lee, J.E]]
+[[Category: Complex]]
+[[Category: Cysteine-rich]]
+[[Category: Glycoprotein]]
+[[Category: Membrane-bound]]