5fai: Difference between revisions
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''' | ==EMG1 N1-Specific Pseudouridine Methyltransferase== | ||
<StructureSection load='5fai' size='340' side='right' caption='[[5fai]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5fai]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FAI FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fai OCA], [http://pdbe.org/5fai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fai RCSB], [http://www.ebi.ac.uk/pdbsum/5fai PDBsum]</span></td></tr> | |||
</table> | |||
[[ | == Disease == | ||
[[ | [[http://www.uniprot.org/uniprot/NEP1_HUMAN NEP1_HUMAN]] Bowen-Conradi syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | |||
[[Category: | [[http://www.uniprot.org/uniprot/NEP1_HUMAN NEP1_HUMAN]] S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity).[UniProtKB:Q06287]<ref>PMID:20047967</ref> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: BROWN, P J]] | |||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
[[Category: | [[Category: DONG, A]] | ||
[[Category: | [[Category: Edwards, A M]] | ||
[[Category: | [[Category: LI, Y]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: | [[Category: TEMPEL, W]] | ||
[[Category: WU, H]] | |||
[[Category: ZENG, H]] | |||
[[Category: Emg1]] | |||
[[Category: Methyltransferase]] | |||
[[Category: Sgc]] | |||
[[Category: Transferase]] | |||
Revision as of 17:26, 20 January 2016
EMG1 N1-Specific Pseudouridine Methyltransferase
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