5fak: Difference between revisions
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==Crystal structure of Double Mutant S12T and N87T of Adenosine/Methylthioadenosine Phosphorylase from Schistosoma mansoni in complex with Adenine== | |||
<StructureSection load='5fak' size='340' side='right' caption='[[5fak]], [[Resolution|resolution]] 1.87Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5fak]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FAK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l6i|4l6i]], [[4l5a|4l5a]], [[4l5c|4l5c]], [[4l5y|4l5y]], [[5f73|5f73]], [[5f76|5f76]], [[5f77|5f77]], [[5f78|5f78]], [[5f7j|5f7j]], [[5f7o|5f7o]], [[5f7x|5f7x]], [[5f7z|5f7z]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5'-thioadenosine_phosphorylase S-methyl-5'-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fak OCA], [http://pdbe.org/5fak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fak RCSB], [http://www.ebi.ac.uk/pdbsum/5fak PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fak ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/I0B503_SCHMA I0B503_SCHMA]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates (By similarity).[HAMAP-Rule:MF_03155] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: S-methyl-5'-thioadenosine phosphorylase]] | |||
[[Category: Brandao-Neto, J]] | [[Category: Brandao-Neto, J]] | ||
[[Category: Pereira, H | [[Category: DeMarco, R]] | ||
[[Category: | [[Category: Pereira, H M]] | ||
[[Category: | [[Category: Torini, J R]] | ||
[[Category: Transferase]] | |||
Revision as of 19:14, 15 December 2016
Crystal structure of Double Mutant S12T and N87T of Adenosine/Methylthioadenosine Phosphorylase from Schistosoma mansoni in complex with Adenine
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