1b6c: Difference between revisions

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[[Image:1b6c.gif|left|200px]]
[[Image:1b6c.gif|left|200px]]


{{Structure
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
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{{STRUCTURE_1b6c| PDB=1b6c  | SCENE= }}  
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b6c OCA], [http://www.ebi.ac.uk/pdbsum/1b6c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1b6c RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12'''
'''CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12'''
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[[Category: Kuriyan, J.]]
[[Category: Kuriyan, J.]]
[[Category: Massague, J.]]
[[Category: Massague, J.]]
[[Category: complex (isomerase/protein kinase)]]
[[Category: Receptor serine/threonine kinase]]
[[Category: receptor serine/threonine kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:07:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:54:33 2008''

Revision as of 08:07, 2 May 2008

File:1b6c.gif

Template:STRUCTURE 1b6c

CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12


Overview

Activation of the type I TGFbeta receptor (TbetaR-I) requires phosphorylation of a regulatory segment known as the GS region, located upstream of the serine/threonine kinase domain in the cytoplasmic portion of the receptor. The crystal structure of a fragment of unphosphorylated TbetaR-I, containing both the GS region and the catalytic domain, has been determined in complex with the FK506-binding protein FKBP12. TbetaR-I adopts an inactive conformation that is maintained by the unphosphorylated GS region. FKBP12 binds to the GS region of the receptor, capping the TbetaR-II phosphorylation sites and further stabilizing the inactive conformation of TbetaR-I. Certain structural features at the catalytic center of TbetaR-I are characteristic of tyrosine kinases rather than Ser/Thr kinases.

About this Structure

1B6C is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12., Huse M, Chen YG, Massague J, Kuriyan J, Cell. 1999 Feb 5;96(3):425-36. PMID:10025408 Page seeded by OCA on Fri May 2 11:07:37 2008

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