5h8s: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5h8s is ~~ON HOLD~~

==Structure of the human GluA2 LBD in complex with GNE3419==

~~Authors~~: ~~Wallweber~~, H.J.A., ~~Lupardus~~, P.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5h8s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H8S OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H8S FirstGlance].

~~Description~~: ~~Structure~~ of the ~~human GluA2 LBD in complex with GNE3419~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=5YC:7-[[ETHYL(PHENYL)AMINO]METHYL]-2-METHYL-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE'>5YC</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

[[Category: Wallweber, H.J.A]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h8s OCA], [http://pdbe.org/5h8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h8s RCSB], [http://www.ebi.ac.uk/pdbsum/5h8s PDBsum]</td></tr>

[[Category: ~~Lupardus, P.J~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Lupardus, P J]]

[[Category: Wallweber, H J.A]]

[[Category: Glun1]]

[[Category: Glun2a]]

[[Category: Nmda]]

[[Category: Receptor]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5h8s is ON HOLD
+==Structure of the human GluA2 LBD in complex with GNE3419==
+<StructureSection load='5h8s' size='340' side='right' caption='[[5h8s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-Authors: Wallweber, H.J.A., Lupardus, P.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5h8s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H8S FirstGlance]. <br>
-Description: Structure of the human GluA2 LBD in complex with GNE3419
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5YC:7-[[ETHYL(PHENYL)AMINO]METHYL]-2-METHYL-[1,3,4]THIADIAZOLO[3,2-A]PYRIMIDIN-5-ONE'>5YC</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h8f|5h8f]], [[5h8h|5h8h]], [[5h8n|5h8n]], [[5h8q|5h8q]], [[5h8r|5h8r]]</td></tr>
-[[Category: Wallweber, H.J.A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h8s OCA], [http://pdbe.org/5h8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h8s RCSB], [http://www.ebi.ac.uk/pdbsum/5h8s PDBsum]</span></td></tr>
-[[Category: Lupardus, P.J]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Lupardus, P J]]
+[[Category: Wallweber, H J.A]]
+[[Category: Glun1]]
+[[Category: Glun2a]]
+[[Category: Nmda]]
+[[Category: Receptor]]
+[[Category: Transport protein]]