DNA damage-binding protein: Difference between revisions
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<StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 (grey) and DDB2 (green) complex with DNA, TMP and tetraethylene glycol (PDB code [[3ei1]]).' scene=''> | <StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 (grey) and DDB2 (green) complex with DNA, TMP and tetraethylene glycol (PDB code [[3ei1]]).' scene=''> | ||
== Function == | |||
'''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2.<ref>PMID:18593899</ref><br /> | '''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2.<ref>PMID:18593899</ref><br /> | ||
== Disease == | |||
Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity. <ref>PMID:18593899</ref> | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of DNA damage-binding protein == | == 3D Structures of DNA damage-binding protein == | ||
