Dual specificity phosphatase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_1ohe| PDB=1ohe | SIZE=400 | SCENE= |right|CAPTION=Human Cdc14B2 core domain (grey) complex with tripeptide (green) and acetyl (PDB code [[1ohe]]). }} | {{STRUCTURE_1ohe| PDB=1ohe | SIZE=400 | SCENE= |right|CAPTION=Human Cdc14B2 core domain (grey) complex with tripeptide (green) and acetyl (PDB code [[1ohe]]). }} | ||
== Function == | |||
'''Dual specificity phosphatase''' (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:<br /> | '''Dual specificity phosphatase''' (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:<br /> | ||
| Line 9: | Line 10: | ||
• Myotubularin<ref>PMID:12847286</ref><br /> | • Myotubularin<ref>PMID:12847286</ref><br /> | ||
• MAPK phosphatase see [[MAP kinase phosphatase]]<br /> | • MAPK phosphatase see [[MAP kinase phosphatase]]<br /> | ||
== Relevance == | |||
Cdc25A and Cdc25B are overexpressed in several types of cancers and their inhibitors are being tested as chemotherapeutic agents. | |||
==3D structures of dual specificity phosphatase== | ==3D structures of dual specificity phosphatase== | ||
