Elastase: Difference between revisions
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[[Elastase]] (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation.<ref>PMID:12059069</ref> For additional details see [[Serine Proteases]]. | [[Elastase]] (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation.<ref>PMID:12059069</ref> For additional details see [[Serine Proteases]]. | ||
== Disease == | |||
Pulmonary emphysema is caused by the destruction of elastic fibre by elastase. Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis. Neutrophil elastase is involved in the blistering in bullose pemphigoid. | |||
==3D structures of elastase== | ==3D structures of elastase== | ||
Revision as of 11:19, 11 January 2016
Elastase (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation.[1] For additional details see Serine Proteases.
Disease
Pulmonary emphysema is caused by the destruction of elastic fibre by elastase. Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis. Neutrophil elastase is involved in the blistering in bullose pemphigoid.
3D structures of elastase
Updated on 11-January-2016
- ↑ Dominici R, Franzini C. Fecal elastase-1 as a test for pancreatic function: a review. Clin Chem Lab Med. 2002 Apr;40(4):325-32. PMID:12059069 doi:https://dx.doi.org/10.1515/CCLM.2002.051
References
Proteopedia Page Contributors and Editors (what is this?)
Alexander Berchansky, Guido Hansen, Jaime Prilusky, Michal Harel
