Elastase

spinqualitylabelsall models Pig elastase (grey, green) complex with chymotrypsin/elastase isoinhibitor (pink, yellow) (PDB code 1eai). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Elastase (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. For additional details see Serine Proteases. Relevance ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation. Disease Pulmonary emphysema is caused by the destruction of elastic fibre by elastase. Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis. Neutrophil elastase is involved in the blistering in bullose pemphigoid. Structural highlights ELA catalytic triad is Ser-His-Asp.

3D structures of elastase

Updated on 11-January-2016

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• MMP12 See Serine Proteases
• MMP16 See Matrix metalloproteinase
• ELA1
  • 3mty, 3mu0, 3mu1, 3mu4, 3mu5, 3mu8, 3mnb, 3mnc, 3mns, 3mnx, 3mo3, 3mo6, 3mo9, 3moc, 3e3t, 2v0b, 2g4t, 2g4u, 2de8, 2blo, 2blq, 2a7c, 2a7j, 1gvk, 1qnj, 1lvy, 3est, 1est, 2oqu, 3odd, 3odf, 2bdc – pELA1 – pig
    
  • 3hgn – pELA1+peptidyl inhibitor – neutron
    
  • 3hgp, 2cv3, 2bdb, 2bcd, 2h1u, 1mmj, 1h9l, 1nes, 4est, 5est, 8est, 7est, 6est - pELA1+peptidyl inhibitor
    
  • 1fzz – pELA1+ONO-6818
    
  • 1qr3, 1qgf, 1bru, 1hv7, 1btu – pELA1+cyclic inhibitor
    
  • 1okx – pELA1 + scyptolin
    
  • 1e34, 1e35, 1e36, 1e37, 1e38 – pELA1-gamma-lactam
    
  • 1eai – pELA1+Ascaris inhibitor
    
  • 2d26 – pELA1+α-1-antitrypsin
    
  • 1fle – pELA1+elafin
    
  • 1b0e, 1b0f – pELA1+MDL
    
  • 2v35 – pELA1+JM54
    
  • 2iot – pELA1+clavulanic acid
    
  • 2de9 – pELA1+tris
    
  • 1uvo, 1uvp, 1lka, 1lkb – pELA1+ions
    
  • 1gwa – pELA1+I3
    
  • 1uo6, 1c1m – pELA1+Xe
    
  • 1l0z, 1l1g - pELA1+Xe+Br
    
  • 2bb4, 2bd2, 2bd3, 2bd4, 2bd5, 2bd7, 2bd8, 2bd9, 1hax, 1hay, 1haz, 1hb0, 1qix – pELA1+beta-casomorphin-7
    
  • 2bda – pELA1+N-acetyl-NPI
    
  • 1mcv – pELA1+squash inhibitor
    
  • 1bma – pELA1+aminimide
    
  • 1elf, 1elg – pELA1+peptidyl hydroxylamine
    
  • 1eld, 1ele, 1elb, 1ela, 1elc, 2est – pELA1+anilide inhibitor
    
  • 1esa, 1esb – pELA1 intermediate
    
  • 1eas, 1eat, 1eau – pELA1+pyridine inhibitor
    
  • 1inc – pELA1+benzoxazinone
    
  • 1jim, 9est, 8est – pELA1+coumarin derivative
    
  • 2fo9, 2foa, 2fob, 2foc, 2fod, 2foe, 2fof, 2fog, 2foh – pELA1+solvent
    
  • 4k89 – PaELA – Pseudomonas aeruginosa
    
  • 3dbk – PaELA+phophoramidon
    
  • 1u4g – PaELA+HPI
    
  • 1ezm - PaELA
    
  • 1elt – ELA - salmon
    
• ELA2
  • 3q76 – hELA2
    
  • 3q77 – hELA2+dihydropyrimidone inhibitor
    
  • 2z7f – hELA2 peptidase domain +antileukoproteinase
    
  • 2rg3 – hELA2+sulfonic inhibitor
    
  • 1h1b, 1ppg, 1hne – hELA2+inhibitor
    
  • 1ppf – hELA2+ovomucoid
    
  • 1b0f – hELA2+MDL101146
    
  • 4nzl – hELA2 + protein
    
  • 4wvp – hELA2 + activity-based probe
    

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