1bgw: Difference between revisions
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'''TOPOISOMERASE RESIDUES 410-1202,''' | '''TOPOISOMERASE RESIDUES 410-1202,''' | ||
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[[Category: Harrison, S C.]] | [[Category: Harrison, S C.]] | ||
[[Category: Wang, J C.]] | [[Category: Wang, J C.]] | ||
[[Category: | [[Category: Dna-binding]] | ||
[[Category: | [[Category: Isomerase]] | ||
[[Category: | [[Category: Phosphorylated nuclear protein]] | ||
[[Category: | [[Category: Topoisomerase]] | ||
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Revision as of 08:29, 2 May 2008
TOPOISOMERASE RESIDUES 410-1202,
Overview
The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws.
About this Structure
1BGW is a Single protein structure of sequence from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1BGW with [Topoisomerases]. Full crystallographic information is available from OCA.
Reference
Structure and mechanism of DNA topoisomerase II., Berger JM, Gamblin SJ, Harrison SC, Wang JC, Nature. 1996 Jan 18;379(6562):225-32. PMID:8538787 Page seeded by OCA on Fri May 2 11:29:46 2008
